A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.
TRowe Enterprise LLC - North Ridgeville since May 2011
Owner
H & R Block Jan 2009 - Apr 2011
Tax Associate
Bureau of the Census Aug 2009 - Sep 2010
Assistant Manager for Technology
The Plain Dealer Jan 1991 - Jan 2009
Assistant Production Manager Systems
Education:
Hudson Valley Community College
AAS, Electrical Technology
University of Hartford
BSET, Engineering Technology
Dr. Rowe graduated from the Columbia University College of Physicians and Surgeons in 1966. He works in Griffin, GA and specializes in Ophthalmology. Dr. Rowe is affiliated with Spalding Regional Hospital.
Jupiter Plastic Surgery Center 2055 Military Trl STE 305, Jupiter, FL 33458 561 746-9400 (phone), 561 744-4619 (fax)
Education:
Medical School University of Miami, Miller School of Medicine Graduated: 1976
Procedures:
Breast Biopsy Breast Reconstruction Mastectomy Bariatric Surgery Hernia Repair Skin Tags Removal
Conditions:
Breast Disorders Inguinal Hernia Malignant Neoplasm of Female Breast Melanoma Ventral Hernia
Languages:
English
Description:
Dr. Rowe graduated from the University of Miami, Miller School of Medicine in 1976. He works in Jupiter, FL and specializes in General Surgery and Medical Oncology. Dr. Rowe is affiliated with Jupiter Medical Center.
Rowe Goodrum MDS 251 W Medical Ctr Blvd STE 300A, Webster, TX 77598 281 338-7693 (phone), 281 338-8849 (fax)
Education:
Medical School Baylor College of Medicine Graduated: 1989
Conditions:
Abnormal Vaginal Bleeding Complicating Pregnancy or Childbirth Conditions of Pregnancy and Delivery Pregnancy-Induced Hypertension Uncomplicated or Low Risk Pregnancy and Delivery
Languages:
English Spanish
Description:
Dr. Rowe graduated from the Baylor College of Medicine in 1989. He works in Webster, TX and specializes in Neonatal-Perinatal Medicine. Dr. Rowe is affiliated with Clear Lake Regional Medical Center and Memorial Hermann Southeast Hospital.
Little Rock , ARDesigner/Owner at Romas Past: Account Manager at IBM, Buyer at Belk I'm a designer.... absolutely love fashion. Also an author (Mocha, must read it and let me know what you think of my first novel) As a motivational speaker, I... I'm a designer.... absolutely love fashion. Also an author (Mocha, must read it and let me know what you think of my first novel) As a motivational speaker, I hope to inspire people with the determination and strength God has given to me.
Co-Founder/Director of R&D at Immune Diagnostics a... Past: Influenza Program Coordinator/Project Leader at Southern Research Institute, Centers for...