Thomas F Mitts

US Patent:

6506731, Jan 14, 2003

Filed:

May 30, 2000

Appl. No.:

09/584001

Inventors:

Lawrence B. Sandberg - Colton CA
Thomas F. Mitts - Visalia CA

Assignee:

Connective Tissue Imagineering LLC - Visalia CA

International Classification:

A61K 3808

US Classification:

514 15, 514 8, 514 9, 514 16, 530304, 530317, 530327, 530328, 530329

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin More preferably, the present invention corresponds to the general formula R -Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine-R.

US Patent:

6777389, Aug 17, 2004

Filed:

Nov 19, 1999

Appl. No.:

09/443631

Inventors:

Thomas F. Mitts - Visalia CA
Lawrence B. Sandberg - Murrieta CA
Philip J. Roos - Loma Linda CA

Assignee:

Connective Tissue Imagineering LLC - Visalia CA

International Classification:

A61K 3800

US Classification:

514 16, 514 17, 514 18, 514 2, 514182, 514177, 514178, 424401

Abstract:

The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal compounds useful in the treatment of problems associated with deficient elastin or conditions that would benefit from increased elastin.

US Patent:

6794362, Sep 21, 2004

Filed:

May 30, 2000

Appl. No.:

09/580893

Inventors:

Lawrence B. Sandberg - Colton CA
Thomas F. Mitts - Visalia CA
Felipe Jimenez, Jr. - Loma Linda CA

Assignee:

Connective Tissue Imagineering LLC - Visalia CA

International Classification:

A16K 3808

US Classification:

514 11, 514 16, 514 17, 514 18, 530317, 530328, 530329, 530330, 424404, 424455, 424489

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides or peptide-like compounds having low molecular weights and which substantially correspond to sequences found in elastin. The present composition specifically includes chemical modification of the peptides described herein, specifically carboxy and amino modification including the addition of amino acids to either end of the peptide fragments.

US Patent:

6809075, Oct 26, 2004

Filed:

May 30, 2000

Appl. No.:

09/580110

Inventors:

Thomas F. Mitts - Visalia CA
Lawrence B. Sandberg - Colton CA

Assignee:

Connective Tissue Imagineering LLC - Visalia CA

International Classification:

A01N 3718

US Classification:

514 2, 514844, 530300, 530317, 530328, 530329, 530330

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin. These peptides are used in conjunction with or in combination with retinoids, preferably tretinoin.

US Patent:

6962904, Nov 8, 2005

Filed:

May 30, 2000

Appl. No.:

09/580156

Inventors:

Lawrence B. Sandberg - Colton CA, US
Thomas F. Mitts - Visalia CA, US

Assignee:

Connective Tissue Imagineering - Visalia CA

International Classification:

A61K038/07
A61K038/08
C07K005/10
C07K007/06

US Classification:

514 16, 514 17, 514 18, 530328, 530329, 530330

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides or peptide-like compounds having low molecular weights and which substantially correspond to sequences found in elastin. The present composition specifically includes chemical modification of the peptides described herein, specifically carboxy and amino modification including the addition of amino acids to either end of the peptide fragments.

US Patent:

7560430, Jul 14, 2009

Filed:

Feb 13, 2004

Appl. No.:

10/778253

Inventors:

Thomas Mitts - Visalia CA, US
Felipe Jimenez - San Bernardino CA, US

Assignee:

Human Matrix Sciences, LLC - Visalia CA

International Classification:

A61K 38/00
C07K 14/00

US Classification:

514 12, 530300

Abstract:

The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides. Methods of using these elastin digest comprising compositions for treating tissues in need of increased elasticity and or Elastin are described.

US Patent:

7566693, Jul 28, 2009

Filed:

Mar 29, 2006

Appl. No.:

11/394354

Inventors:

Felipe Jimenez - San Bernardino CA, US
Thomas Mitts - Visalia CA, US
Aleksander Hinek - Toronto, CA

Assignee:

Human Matrix Sciences, LLC - Visalia CA
The Hospital for Sick Children - Toronto, Ontario

International Classification:

C07K 14/00

US Classification:

514 2, 530300

Abstract:

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

US Patent:

7666829, Feb 23, 2010

Filed:

Feb 22, 2005

Appl. No.:

11/062377

Inventors:

Thomas Mitts - Visalia CA, US
Felipe Jimenez - San Bernardino CA, US
Aleksander Hinek - Toronto, CA
Severa Bunda - Toronto, CA

Assignee:

Human Matrix Sciences, LLC - Visalia CA
The Hospital For Sick Children - Toronto

International Classification:

A61K 31/00
A61K 8/02
A61K 33/26
A01N 61/00
A01N 59/16

US Classification:

514 1, 424401, 424647

Abstract:

The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.