Thomas A Mich

US Patent:

6891059, May 10, 2005

Filed:

Jan 11, 2001

Appl. No.:

10/182656

Inventors:

Mark Joseph Burk - Landbeach, GB
Om Prakash Goel - Ann Arbor MI, US
Marvin Simon Hoekstra - Holland MI, US
Thomas Frederick Mich - Ann Arbor MI, US
Thomas Mulhern - Hudsonville MI, US
James A. Ramsden - Cambridge, GB

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07C255/03

US Classification:

558441

Abstract:

This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

US Patent:

43159338, Feb 16, 1982

Filed:

Sep 24, 1980

Appl. No.:

6/190154

Inventors:

Thomas F. Mich - Ann Arbor MI
Theodore H. Haskell - Ann Arbor MI
Marland P. Hutt - Saline MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31505
C07D49970

US Classification:

424251

Abstract:

Novel organic amide compounds which are N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-(acylaminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

US Patent:

40227618, May 10, 1977

Filed:

Jan 19, 1976

Appl. No.:

5/650097

Inventors:

Francis John Tinney - Ann Arbor MI
Ernest D. Nicolaides - Ann Arbor MI
Marland Paul Hutt - Saline MI
Thomas Frederick Mich - Ann Arbor MI

Assignee:

Parke, Davis & Company - Detroit MI

International Classification:

C07C10352

US Classification:

2601125LH

Abstract:

New tripeptides having the formula A-R. sub. 1 -Ser(benzyl)-Tyr (benzyl)-R. sub. 2 wherein A is t-butoxycarbonyl or cyclohexyl carbonyl, R. sub. 1 is Trp, His(benzyl), Cys(benzyl) or Pro and R. sub. 2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.

US Patent:

46044019, Aug 5, 1986

Filed:

Jul 20, 1984

Appl. No.:

6/633151

Inventors:

Thomas F. Mich - Ann Arbor MI
Townley P. Culbertson - Ann Arbor MI
John M. Domagala - Canton MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3147
C07D21522

US Classification:

514312

Abstract:

Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

US Patent:

45501033, Oct 29, 1985

Filed:

Jul 20, 1984

Appl. No.:

6/632999

Inventors:

Thomas F. Mich - Ann Arbor MI
Townley P. Culbertson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A01N 4342
C07D45504

US Classification:

514210

Abstract:

Novel 10-amino-9-fluoro- and 9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-(heterocyclyl)1H,5H-benzo (ij)-2-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

US Patent:

40923096, May 30, 1978

Filed:

Apr 27, 1977

Appl. No.:

5/791270

Inventors:

Thomas Frederick Mich - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D49968

US Classification:

2602391

Abstract:

Derivatives of amoxicillin having broad spectrum antibacterial activity are disclosed. In addition, the following methods for preparing the compounds are provided (a) reacting the free amino acid amoxicillin or the acid salt or silylated derivative thereof with a reactive derivative of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinic acid and (b) reacting the free amino acid 6-aminopenicillanic acid or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-(+)-N-(1,2-dihydro-2-oxonicotinyl)-2-(p-hydroyphenyl)glycine.

US Patent:

52816125, Jan 25, 1994

Filed:

May 27, 1988

Appl. No.:

7/200090

Inventors:

John M. Domagala - Canton MI
Thomas F. Mich - Ann Arbor MI
Jeffrey B. Nichols - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31435
C07D47104

US Classification:

514300

Abstract:

Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

US Patent:

46380671, Jan 20, 1987

Filed:

Aug 12, 1985

Appl. No.:

6/764357

Inventors:

Townley P. Culbertson - Ann Arbor MI
John M. Domagala - Canton MI
Thomas F. Mich - Ann Arbor MI
Jeffrey B. Nichols - Ypsilanti MI

Assignee:

Warner-Lambert Co. - Morris Plains NJ

International Classification:

C07D47104
C07D40114
C07D21502

US Classification:

546 15

Abstract:

Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.