Thomas C Hutsell

US Patent:

56504470, Jul 22, 1997

Filed:

Mar 17, 1994

Appl. No.:

8/214372

Inventors:

Larry K. Keefer - Bethesda MD
Thomas C. Hutsell - North Oaks MN

Assignee:

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
Comedicus, Incorporated - Long Lake MN

International Classification:

A01N 3326
A61K 4730

US Classification:

5147724

Abstract:

Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N. sub. 2 O. sub. 2. sup. - functional group a compound comprising a nitric oxide-releasing N. sub. 2 O. sub. 2. sup. - functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized.

US Patent:

54829259, Jan 9, 1996

Filed:

Mar 17, 1994

Appl. No.:

8/210043

Inventors:

Thomas C. Hutsell - North Oaks MN

Assignee:

Comedicus Incorporated - Long Lake MN

International Classification:

A61K 3808
A61K 3816
A61K 3817
A61K 3831

US Classification:

514 11

Abstract:

Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological conditions of releasing in vivo dual active ingredients, the NO and the known cardiovascular agent. The complexes are used for treating cardiovascular diseases and for the prophylactic or therapeutic treatment of restenosis.