Master of Science, Masters, Bachelors, Bachelor of Science
School / High School:
Colorado State University
1979 to 1983
Specialities:
Biology, Biophysics
Skills
Immunology • Flow Cytometry • Cell • Assay Development • Drug Discovery • Oncology • Pharmaceutical Industry • Cell Biology • Biomarkers • In Vivo • Cell Culture • Laboratory • Molecular Biology • Biotechnology • Life Sciences • In Vitro • Lifesciences • Biochemistry • Immunoassays • Cancer • Drug Development • Pharmacology • Translational Research • Data Analysis • Cell Based Assays • Microscopy • Scientific Writing • Toxicology • Fluorescence Microscopy • Genetics • Genomics • High Throughput Screening • Elisa • R&D • Science • Animal Models • Cancer Research • Translational Medicine • Fluorescence • Pharmaceuticals
Industries
Pharmaceuticals
Us Patents
Inhibition Of Vacuolar Proton Atpase Activity And/Or The Modulation Of Acidic Organelle Function Sensitizes Cells To Radiation, Chemotherapy And Biological Agents
Shoshana Paglin - New York NY, US Joachim Yahalom - New York NY, US Timothy Hollister - Chicago IL, US Thomas Delohery - Oakland NJ, US
International Classification:
A61K031/7048 A61N005/00
US Classification:
514/028000, 600/001000
Abstract:
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or chemotherapy exposure through inhibition of V-H-ATPase. In particular, the formation and/or acidification of acidic vesicular organelles (AVOs) may be prevented or decreased by inhibiting the activity of vacuolar proton ATPase (“V-H-ATPase”). The methods and compositions of the invention are based on the observation that (i) following irradiation surviving cancer cells accumulate AVOs and that their acidification is mediated by V-H-ATPase; (ii) surviving colonies of cells contain higher levels of AVOs; and (iii) inhibition of V-H-ATPase decreases the clonogenic survival of cells irradiated or exposed to chemotherapeutic agents. These observations led to the conclusion that V-H-ATPase activity and AVO function serve to protect cells from radiation and chemotherapy damage. In addition, agents such as bFGF, TNF-, PMA, rapamycin and tamoxifen were shown to be inducers of acidic organelle formation. Therefore signal transduction pathways mediated by these agents provide targets for drug screening assays designed to identify inhibitors of V-H-ATPase activity and AVO formation/acidification. The present invention may be used to treat cancer subjects through sensitization of neoplastic cells to the toxic effects of radiation and chemotherapy.
Merck Aug 2013 - Sep 2015
Principal Scientist
Sanofi Oct 2001 - Apr 2012
Principal Research Investigator
Rockefeller University Jun 2001 - Oct 2001
Supervisor and Manager Flow Cytometry Core
Memorial Sloan Kettering Cancer Center Jul 1991 - Jun 2001
Supervisor and Manager Flow Cytometry Core
Columbia University Cancer Center Jun 1985 - Nov 1991
Supervisor and Manager Flow Cytometry Core
Education:
Colorado State University 1979 - 1983
Master of Science, Masters, Bachelors, Bachelor of Science, Biology, Biophysics
Skills:
Immunology Flow Cytometry Cell Assay Development Drug Discovery Oncology Pharmaceutical Industry Cell Biology Biomarkers In Vivo Cell Culture Laboratory Molecular Biology Biotechnology Life Sciences In Vitro Lifesciences Biochemistry Immunoassays Cancer Drug Development Pharmacology Translational Research Data Analysis Cell Based Assays Microscopy Scientific Writing Toxicology Fluorescence Microscopy Genetics Genomics High Throughput Screening Elisa R&D Science Animal Models Cancer Research Translational Medicine Fluorescence Pharmaceuticals
Youtube
Irish Artist Thomas Delohery Interview, Part 1
Irish Artist Thomas Delohery being Interviewed by Jason Baxter for Bre...
Category:
People & Blogs
Uploaded:
20 Nov, 2009
Duration:
5m 42s
A Poetic Tribute To Richard Harris
revivalpoetryboo... ALWAYS PUSHING THE PULL DOOR. Poems by Mark Whela...
Category:
People & Blogs
Uploaded:
24 Dec, 2007
Duration:
7m 36s
A Man Called Harris
revivalpoetryboo... ALWAYS PUSHING THE PULL DOOR. Poems by Mark Whela...
Category:
People & Blogs
Uploaded:
29 Dec, 2007
Duration:
5m 1s
Thomas Delohery
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Thomas Delohery presents a painting to the Je...
The multi-award winning artist Thomas Delohery's exhibition, Night But...
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