Theodore W Kahn

US Patent:

7105332, Sep 12, 2006

Filed:

Apr 18, 2005

Appl. No.:

11/108389

Inventors:

André Abad - W. Des Moines IA, US
Ronald D. Flannagan - Grimes IA, US
Rafael Herrmann - Wilmington DE, US
Theodore W. Kahn - Durham NC, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
James F. H. Wong - Johnston IA, US

Assignee:

E.I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C12N 9/50
C12N 15/00
A61K 38/00

US Classification:

435219, 800279, 530350

Abstract:

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of encoding δ-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

US Patent:

7605304, Oct 20, 2009

Filed:

Oct 23, 2001

Appl. No.:

10/032717

Inventors:

Andre R. Abad - West Des Moines IA, US
Nicholas B. Duck - Apex NC, US
Xiang Feng - West Des Moines IA, US
Ronald D. Flannagan - Grimes IA, US
Theodore W. Kahn - Johnston IA, US
Lynne E. Sims - Polk City IA, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

A01H 5/00
A01H 5/10
C12N 15/82
C12N 15/32

US Classification:

800302, 800279, 536 2371

Abstract:

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of encoding δ-endotoxins having pesticidal activity against pests of the order Coleoptera. The invention further provides mutagenized nucleic acids that have been modified to encode endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, expression cassettes comprising such nucleic acids, and transformed plants and seeds comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

US Patent:

7696412, Apr 13, 2010

Filed:

Apr 16, 2003

Appl. No.:

10/414637

Inventors:

Andre R. Abad - West Des Moines IA, US
Nicholas B. Duck - Apex NC, US
Xiang Feng - West Des Moines IA, US
Ronald D. Flannagan - Grimes IA, US
Theodore W. Kahn - Johnston IA, US
Lynne E. Sims - Polk City IA, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

A01H 5/00
A01H 5/10
C12N 15/82
C12N 15/32

US Classification:

800302, 800279, 536 2371

Abstract:

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of encoding δ-endotoxins having pesticidal activity against pests of the order Coleoptera. The invention further provides mutagenized nucleic acids that have been modified to encode endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, expression cassettes comprising such nucleic acids, and transformed plants and seeds comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

US Patent:

7803925, Sep 28, 2010

Filed:

Jul 1, 2008

Appl. No.:

12/166239

Inventors:

Nadine Carozzi - Raleigh NC, US
Michael G. Koziel - Raleigh NC, US
Tracy Hargiss - Kernersville NC, US
Nicholas B. Duck - Apex NC, US
Theodore W. Kahn - Durham NC, US

Assignee:

Athenix Corp. - Research Triangle Park NC

International Classification:

C07H 21/04
C12P 21/02
A01N 33/00
A61K 31/7052

US Classification:

536 2371, 435 691, 514 44 R

Abstract:

Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 15, 17, or 19, or the nucleotide sequence set forth in SEQ ID NO:1, 3, 14, 16, or 18, as well as variants and fragments thereof.

US Patent:

7923602, Apr 12, 2011

Filed:

Jun 14, 2007

Appl. No.:

11/762886

Inventors:

Nadine Carozzi - Raleigh NC, US
Nicholas Duck - Apex NC, US
Theodore Kahn - Apex NC, US
Nalini Desai - Chapel Hill NC, US

Assignee:

Athenix Corp. - Morrisville NC

International Classification:

A01H 5/00
A01H 5/10
C12N 15/82
C12N 15/32
C12N 1/21

US Classification:

800302, 536 2371, 4353201, 4352523, 435418, 424 932, 800279

Abstract:

Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, or 38, or the nucleotide sequence set forth in SEQ ID NO: 1, 3, 5, 7, 9, 11, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, or 37, as well as variants and fragments thereof.

US Patent:

8147856, Apr 3, 2012

Filed:

Feb 2, 2009

Appl. No.:

12/364335

Inventors:

Nadine Carozzi - Raleigh NC, US
Nicholas Duck - Apex NC, US
Theodore Kahn - Apex NC, US
Nalini Desai - Chapel Hill NC, US
Shruti Agarwal - Durham NC, US
Daniel John Tomso - Bahama NC, US
Rong Guo - Durham NC, US
Julia Daum - Apex NC, US

Assignee:

Athenix Corp. - Morrisville NC

International Classification:

A01N 63/02
C12N 15/32
C12P 21/04
C07K 14/325

US Classification:

424405, 530350, 514 45, 435 701

Abstract:

Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, or 38, or the nucleotide sequence set forth in SEQ ID NO:1, 3, 5, 7, 9, 11, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, or 37, as well as variants and fragments thereof.

US Patent:

8188036, May 29, 2012

Filed:

May 27, 2009

Appl. No.:

12/472997

Inventors:

Andre R. Abad - West Des Moines IA, US
Nicholas B. Duck - Apex NC, US
Xiang Feng - West Des Moines IA, US
Ronald D. Flannagan - Grimes IA, US
Theodore W. Kahn - Johnston IA, US
Lynne E. Sims - Polk City IA, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

A01N 37/18

US Classification:

514 45

Abstract:

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of encoding δ-endotoxins having pesticidal activity against pests of the order Coleoptera. The invention further provides mutagenized nucleic acids that have been modified to encode endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

US Patent:

8541366, Sep 24, 2013

Filed:

Sep 12, 2008

Appl. No.:

12/209354

Inventors:

Nadine Carozzi - Raleigh NC, US
Nalini Desai - Chapel Hill NC, US
Daniel J. Tomso - Bahama NC, US
Vadim Beilinson - Cary NC, US
Theodore Kahn - Cary NC, US

Assignee:

Athenix Corporation - Morrisville NC

International Classification:

A01N 37/18
C07K 14/325

US Classification:

514 45

Abstract:

Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided, particularly synthetically-derived coding sequences. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:9, 11, 13, 15, or 18, or the nucleotide sequence set forth in SEQ ID NO:1, 2, 4, 6, 7, 8, 10, 12, 14, 16, or 17, as well as variants and fragments thereof.

Author:

Theodore Charles Kahn

ISBN #:

0080178626

Author:

Theodore Charles Kahn

ISBN #:

0398023263