GEOFFREY M. WAHL - SAN DIEGO CA, US NORIAKI SHIMIZU - HIROSHIMA, JP TERU KANDA - LA JOLLA CA, US H. MICHAEL SHEPARD - RANCHO SANTA FE CA, US
International Classification:
C12Q001/68 G01N033/574 A61K049/00
US Classification:
435006000, 435007230, 424009600
Abstract:
This invention provides methods by which test substances can be screened for their ability to inhibit, enhance or eliminate double minute (DM) or extrachromosomal DNA by micronucleation in cells. This invention also provides a method for inducing maturation or death of a cell having the capacity to generate micronuclei. It also provides a method of treating a disease in a subject, the cells correlated with the disease having DM and extrachromosomal DNA as well as the capacity to generate micronuclei to capture them. Further provided is a method of detecting chromosomal and extrachromosomal DNA in a cell.