Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic conjugates of the iRNA agents and amphipathic micelle-forming molecules with extended hydrophilic chains. Also disclosed are methods of using the pharmaceutical formulations to increase delivery of an iRNA agent to an intracellular target, and to decrease extracellular nuclease degradation of an iRNA agent in the formulations.
Compounds And Methods For Targeted Immune System Delivery
Juan Sabastian PAPPALARDO - Escobar, AR Micaela TONIUTTI - Udine, IT Stefano SALMASO - Abano Terme, IT Tatyana S. LEVCHENKO - Revere MA, US Vladimir TORCHILIN - Charlestown MA, US
Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed.
Resumes
Research Assistant Professor Pharmaceutical Scienc
Northeastern University
Research Assistant Professor Pharmaceutical Scienc
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Flow Cytometry Elisa In Vivo Cell Culture Western Blotting Drug Delivery Hplc In Vitro Cell Assay Development Fluorescence Microscopy Mass Spectrometry Drug Discovery Biochemistry Lifesciences Tissue Culture Lc Ms Animal Models Protein Chemistry Confocal Microscopy Rt Pcr Biotechnology Immunology Chromatography Nanoparticles Immunohistochemistry Cell Biology Molecular Biology Microscopy Cancer Pharmaceutical Research Uv/Vis Sds Page Gel Electrophoresis Protein Expression Immunoassays Protein Purification Pharmacology Antibodies Facs Life Sciences
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