Tanya P Lin

US Patent:

7842668, Nov 30, 2010

Filed:

Sep 29, 2006

Appl. No.:

11/541344

Inventors:

Heather Flores - Hayward CA, US
Tanya P. Lin - Bronx NY, US
Timothy C. Matthews - San Francisco CA, US
Roger Pai - Los Altos CA, US
Zahra Shahrokh - Weston MA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 38/00

US Classification:

514 12, 514 2

Abstract:

The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

US Patent:

8470969, Jun 25, 2013

Filed:

Jun 23, 2010

Appl. No.:

12/822093

Inventors:

Heather Flores - Hayward CA, US
Tanya P. Lin - Tucson AZ, US
Timothy C. Matthews - San Mateo CA, US
Roger Pai - Los Altos CA, US
Zahra Shahrokh - Weston MA, US
Evan E. Shave - Gladesville, AU
Patricia A. Rancatore - San Mateo CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 1/00
C07K 14/00
C07K 17/00

US Classification:

530350, 530414, 514 193, 514 194

Abstract:

The present invention relates generally to Apo2L/TRAIL purification involving crystallization.

US Patent:

20050020498, Jan 27, 2005

Filed:

Feb 3, 2004

Appl. No.:

10/771254

Inventors:

Heather Flores - Hayward CA, US
Tanya Lin - Bronx NY, US
Timothy Matthews - Millbrae CA, US
Roger Pai - Los Altos CA, US
Zahra Shahrokh - Weston MA, US

International Classification:

A61K038/17
A61K031/198

US Classification:

514012000, 514565000

Abstract:

The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

US Patent:

20050080006, Apr 14, 2005

Filed:

Nov 12, 2002

Appl. No.:

10/495353

Inventors:

Tanya Lin - Bronx NY, US
Zahra Shahrokh - Weston MA, US
Heather Flores - Hayward CA, US
Roger Pai - Los Altos CA, US
Timothy Matthews - San Francisco CA, US

International Classification:

A61K038/17

US Classification:

514012000

Abstract:

The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

US Patent:

20060009387, Jan 12, 2006

Filed:

May 24, 2005

Appl. No.:

11/136842

Inventors:

Heather Flores - Hayward CA, US
Tanya Lin - Bronx NY, US
Timothy Matthews - Millbrae CA, US
Roger Pai - Los Altos CA, US
Zahra Shahrokh - Weston MA, US

Assignee:

GENENTECH, INC. - South San Francisco CA

International Classification:

A61K 38/17

US Classification:

514012000

Abstract:

The present invention relates generally to Apo2L/TRAIL purification involving crystallization.

US Patent:

20110054153, Mar 3, 2011

Filed:

May 10, 2006

Appl. No.:

11/915110

Inventors:

Heather Flores - Hayward CA, US
Tanya Lin - Tucson AZ, US
Timothy Matthews - San Mateo CA, US
Roger Pai - Los Altos Hills CA, US
Zahra Shahrokh - Weston MA, US

International Classification:

C07K 1/00

US Classification:

530414, 530416

Abstract:

The present invention relates generally to Apo2L/TRAIL purification involving crystallization.

US Patent:

20110245185, Oct 6, 2011

Filed:

Oct 21, 2010

Appl. No.:

12/925458

Inventors:

Heather Flores - Hayward CA, US
Tanya P. Lin - Bronx NY, US
Timothy C. Matthews - San Francisco CA, US
Roger Pai - Los Altos CA, US
Zahra Shahrokh - Weston MA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 38/19
C07K 14/525
A61P 35/00
C12P 21/06
C12N 5/02
A61M 5/00

US Classification:

514 193, 530351, 435 691, 435375, 604187

Abstract:

The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.