Tamil Arasu

US Patent:

20110130397, Jun 2, 2011

Filed:

Sep 21, 2007

Appl. No.:

12/441932

Inventors:

Soongyu Choi - Skillman NJ, US
Arthur Branstrom - East Windsor NJ, US
Scott A. Gothe - Morris Plains NJ, US
Richard Lipman - Monmouth Junction NJ, US
Tamil Arasu - Edison NJ, US
Richard G. Wilde - Somerville NJ, US

International Classification:

A61K 31/428
C07D 417/04
C07D 417/14
A61K 31/433
A61K 31/427
A61K 31/4439
C07D 413/14
A61K 31/423
C07D 473/30
A61K 31/52
C07D 405/14
A61K 31/506
C07D 473/34
C07D 487/04
A61K 31/519
A61K 31/5377
A61P 31/04
A01N 43/90
A01N 43/84
A01N 43/824
A01N 43/78

US Classification:

5142342, 548162, 514367, 548141, 514363, 548159, 548195, 514371, 5462701, 514338, 548222, 514375, 544276, 51426323, 544328, 514256, 544277, 544262, 5142621, 544118

Abstract:

Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for preventing or inhibiting bacterial proliferation as well as methods for preventing, treating, and/or managing a bacterial infection using such compounds and compositions.

US Patent:

20120202763, Aug 9, 2012

Filed:

May 27, 2010

Appl. No.:

13/321257

Inventors:

Neil Almstead - Princeton NJ, US
Tamil Arasu - Edison NJ, US
Soongyu Choi - Skillman NJ, US
Jeffrey Allen Campbelll - Hilton Head Island SC, US
Donald Corson - Erie CO, US
Thomas W. Davis - South Orange NJ, US
Jason D. Graci - Scranton PA, US
Zhengxian Gu - Princeton NJ, US
Peter Seong Woo Hwang - Edison NJ, US
William Lennox - Bedminster NJ, US
Harry H. Miao - Wellesley MA, US
Langdon Miller - Seatle WA, US
Young-Choon Moon - Belle Mead NJ, US
Hongyan Qi - Plainsboro NJ, US
Christopher Trotta - Somerset NJ, US
Marla L. Weetall - Morristown NJ, US

Assignee:

PTC THERAPEUTICS, INC - South Plainfield NJ

International Classification:

A61K 31/437
A61K 31/496
A61K 31/5377
A61K 31/506
A61K 31/541
A61K 31/53
A61K 31/497
A61P 35/00
A61P 31/12
A61P 19/02
A61P 37/00
A61P 3/04
A61P 17/06
A61P 9/10
A61P 27/02
A61P 27/06
A61P 27/14
A61P 3/02
A61P 29/00
A61P 11/00
A61P 13/12
A61P 9/12
A61P 17/02
A61P 1/04
A61P 31/22
A61P 33/02
A61P 17/12
A61P 9/00
A61P 7/06
A61P 19/04
A61P 31/04
A61P 27/10
A61P 31/14
A61P 31/16
A61P 31/20
A61P 31/18
C12N 5/09
C12N 5/071
C07H 19/056
A61K 31/7056
C07F 7/10
A61K 31/695
A61P 17/10
C07D 471/04

US Classification:

514 43, 546 85, 544361, 544126, 544331, 544319, 514292, 51425303, 5142328, 514275, 514269, 544 586, 5142282, 544122, 544212, 514245, 544405, 51425505, 435366, 435375, 546 87, 536 287, 544182, 514242, 546 14, 514 63

Abstract:

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

US Patent:

20100069380, Mar 18, 2010

Filed:

Sep 21, 2007

Appl. No.:

12/441929

Inventors:

Soongyu Choi - Skillman NJ, US
Arthur Branstrom - East Windsor NJ, US
Scott A. Gothe - Morris Plains NJ, US
Richard Lipman - Monmouth Junction NJ, US
Tamil Arasu - Edison NJ, US
Richard G. Wilde - Somerville NJ, US

International Classification:

C07D 491/052
A61K 31/5377
A61K 31/4741
C07D 491/22
C07D 491/16
A61P 31/04
A61K 31/4743
A61K 31/506
C07D 491/147
C07D 491/153
A61K 31/4375

US Classification:

5142325, 435 18, 5142328, 514274, 514278, 514285, 514287, 514288, 514291, 514293, 514300, 544 80, 544126, 544317, 546 18, 546 62, 546 65, 546 66, 546 83, 546 89, 546123

Abstract:

Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for screening and identifying compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase. In particular, provided herein are assays for the identification of compounds that inhibit or reduce the activity of a bacterial peptidyl tRNA hydrolase. The methods provided herein provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, and managing a bacterial infection or one or more symptoms thereof. Further provided herein are methods for preventing or inhibiting bacterial proliferation as well as methods for preventing, treating, and/or managing a bacterial infection using such compounds and compositions.

US Patent:

20150080362, Mar 19, 2015

Filed:

Aug 29, 2012

Appl. No.:

14/241372

Inventors:

Arthur Branstrom - East Windsor NJ, US
Vara Prasad Venkata Nagendra Josyula - Superior Township MI, US
Michael Andrew Arnold - Flemington NJ, US
Gary Karp - Princeton Junction NJ, US
Jiashi Wang - Monmouth Junction NJ, US
Tamil Arasu - Edison NJ, US
John David Baird - Piscataway NJ, US
Wu Du - Cranbury NJ, US
Olya Ginzburg - Bloomfield NJ, US
Yi Jin Kim Gorske - Brunswick ME, US
Jana Narasimhan - Scotch Plains NJ, US
Srinivasa Peddi - Piscataway NJ, US
Hongyan Qi - Plainsboro NJ, US
Sean Wesley Smith - Hamilton NJ, US
Anthony Allan Turpoff - Hillsborough NJ, US
Richard Gerald Wilde - Somerville NJ, US
Tianle Yang - Mountainside NJ, US
Nanjing Zhang - Princeton NJ, US
Xiaoyan Zhang - Belle Mead NJ, US

Assignee:

PTC THERAPEUTICS, INC. - South Plainfield NJ

International Classification:

C07D 515/04
A61K 31/4412
C07D 401/10
A61K 45/06
A61K 31/5377
A61K 31/4439
C07D 487/08
A61K 31/5383
C07D 213/80
A61K 31/4427

US Classification:

5142102, 546298, 514350, 546296, 514348, 5462681, 544131, 5142355, 5462764, 514343, 5462767, 514338, 544105, 5142305

Abstract:

The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.