Tamara Minko - Edison NJ, US Patrick J. Sinko - Lebanon NJ, US Stanley Stein - East Brunswick NJ, US
Assignee:
Rutgers, The State University of New Jersey - New Brunswick NJ
International Classification:
A61P 35/00 A61K 38/09 A61K 38/10
US Classification:
424 145, 514 193, 514 214, 514 216
Abstract:
The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.
Enhanced Oral And Transcompartmental Delivery Of Therapeutic Or Diagnostic Agents
Srinivasan Ramanathan - Mountain View CA, US Stanley Stein - East Brunswick NJ, US Michael Leibowitz - Manalapan NJ, US Patrick Sinko - Lebanon NJ, US Tamara Minko - Edison NJ, US Gregory Williams - Warren NJ, US Xiaoping Zhang - Piscataway NJ, US Shahrair Pooyan - Monnt Kisco NY, US Seong Park - Piscataway NJ, US Bo Qiu - East Brunswick NJ, US Pankaj Paranjpe - Piscataway NJ, US
International Classification:
A61K009/14
US Classification:
424/486000
Abstract:
The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
Complex Drug Delivery Composition And Method For Treating Cancer
Tamara Minko - Edison NJ, US Patrick Sinko - Lebanon NJ, US Stanley Stein - East Brunswick NJ, US
International Classification:
A61K038/17
US Classification:
514002000
Abstract:
The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.
Enhanced Oral And Transcompartmental Delivery Of Therapeutic Or Diagnostic Agents
Srinivasan Ramanathan - Mountain View CA, US Stanley Stein - East Brunswick NJ, US Michael Leibowitz - Manalapan NJ, US Patrick Sinko - Lebanon NJ, US Tamara Minko - Edison NJ, US Gregory Williams - Warren NJ, US Xiaoping Zhang - Piscataway NJ, US Shahrair Pooyan - Monnt Kisco NY, US Seong Park - Piscataway NJ, US Bo Qiu - East Brunswick NJ, US Pankaj Paranjpe - Piscataway NJ, US
International Classification:
A61K 9/20
US Classification:
424465000
Abstract:
The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
Enhanced Oral Transcompartmental Delivery Of Therapeutic Or Diagnostic Agents
Srinivasan Ramanathan - Mountain View CA, US Stanley Stein - East Brunswick NJ, US Michael Leibowitz - Manalapan NJ, US Patrick J. Sinko - Lebanon NJ, US Tamara Minko - Edison NJ, US Gregory C. Williams - Warren NJ, US Xiaoping Zhang - Piscataway NJ, US Shahrair Pooyan - Mount Kisco NJ, US Seong Hee Park - Piscataway NJ, US Bo Qiu - East Brunswick NJ, US Pankaj Paranjpe - Piscataway NJ, US
International Classification:
C07K 7/06
US Classification:
530327
Abstract:
The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
E2F As A Target Of Hormone Refractory Prostate Cancer
Joseph R. Bertino - Brantford CT, US Debabrata Banerjee - Bellerose NY, US Tamara Minko - Somerset NJ, US Olga B. Garbuzenko - Highland Park NJ, US Xiaoqi Xie - Lawrenceville NJ, US John E. Kerrigan - East Windsor NJ, US Emine E. Abali - Tenafly NJ, US Kathleen W. Scotto - Washington Crossing PA, US
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ
The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided.
Enhanced Oral Transcompartmental Delivery Of Therapeutic Or Diaganostic Agents
Srinivasan Ramanathan - Mountain View CA, US Stanley Stein - East Brunswick NJ, US Michael Leibowitz - Manalapan NJ, US Patrick J. Sinko - Annandale NJ, US Tamara Minko - Edison NJ, US Gregory C. Williams - Warren NJ, US Xiaoping Zhang - Piscataway NJ, US Shahrair Pooyan - Mount Kisco NY, US Seong Hee Park - Piscataway NJ, US Bo Qiu - Clinton NJ, US Pankaj Paranjpe - Piscataway NJ, US
Assignee:
Rutgers, The State University of New Jersey - New Brunswick NJ
International Classification:
A61K 47/48 A61K 38/08 A61K 47/34
US Classification:
514 215, 514 219
Abstract:
The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
Compositions And Methods For Delivering Nucleic Acid Molecules And Treating Cancer
Tamara Minko - Somerset NJ, US Lorna Rodriguez-Rodriguez - East Brunswick NJ, US Olga B. Garbuzenko - Highland Park NJ, US Oleh Taratula - Corvallis OR, US Vatsal Shah - New Brunswick NJ, US
Assignee:
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ
The present invention provides compositions and methods for the delivery of nucleic acids to a cell. The present invention additionally provides compositions and methods for the treatment of a disease or disorder, particularly cancer.