Sylvia A Evans

US Patent:

7625874, Dec 1, 2009

Filed:

Apr 11, 2007

Appl. No.:

11/734267

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Wenlai Zhou - San Diego CA, US
Michael G Rosenfeld - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 48/00
C07H 21/02
C07H 21/04
C12N 15/63

US Classification:

514 44, 536 231, 536 245, 4353201

Abstract:

The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.

US Patent:

7745113, Jun 29, 2010

Filed:

Feb 2, 2004

Appl. No.:

10/544053

Inventors:

Sylvia M. Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Alessandra Moretti - La Jolla CA, US
Kenneth R. Chien - La Jolla CA, US
Karl-Ludwig Laugwitz - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 1/68
G01N 33/567
C12N 5/71

US Classification:

435 6, 435366, 435 72

Abstract:

The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.

US Patent:

7981615, Jul 19, 2011

Filed:

Nov 2, 2009

Appl. No.:

12/611047

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Wenlai Zhou - San Diego CA, US
Michael G. Rosenfeld - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04
C07K 16/00

US Classification:

435 6, 536 231, 536 245, 5303871

Abstract:

The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.

US Patent:

8323909, Dec 4, 2012

Filed:

Apr 29, 2010

Appl. No.:

12/770597

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Lizhu Lin - La Jolla CA, US
Ken Chien - La Jolla CA, US
Alessandra Moretti - La Jolla CA, US
Karl Laugwitz - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 5/00
G01N 33/53

US Classification:

435 71, 435375, 435377

Abstract:

The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.

US Patent:

20080108090, May 8, 2008

Filed:

May 2, 2007

Appl. No.:

11/799839

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Lizhu Lin - La Jolla CA, US
Ken Chien - La Jolla CA, US
Alessandra Moretti - La Jolla CA, US
Karl Laugwitz - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/53

US Classification:

435 721

Abstract:

The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.

US Patent:

20100285580, Nov 11, 2010

Filed:

Nov 14, 2008

Appl. No.:

12/742248

Inventors:

Sylvia Evans - Del Mar CA, US
Yunfu Sun - San Diego CA, US
Ju Chen - San Diego CA, US
Taylor Liu - Salinas CA, US

International Classification:

C12N 5/071

US Classification:

435354, 435325, 435366

Abstract:

The present invention provides isolated stem cells and progenitor cells, including HCN4-expressing CCS progenitor cells, HCN4- and Islet 1-expressing sinoatrial node cells or progenitor cells thereof, and Islet 1-expressing cardiovascular stem cells that do not express HCN4. The invention further provides differentiated cell types derived from the CCS progenitor cells and cardiovascular stem cells of the invention. In addition, the invention provides methods of differentiating the cells of the invention, methods for screening for agents that affect the differentiation of the cells of the invention, methods for evaluating the potential toxicity of drugs using the cells of the invention, cell therapy using the cells of the invention, and methods of treating heart arrhythmia by ablating HCN4-expressing cells.

US Patent:

6451594, Sep 17, 2002

Filed:

Sep 10, 1999

Appl. No.:

09/394110

Inventors:

Kenneth R. Chien - La Jolla CA
Yibin Wang - Brookville MD
Sylvia Evans - Del Mar CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 1500

US Classification:

4353201, 435455, 536 241, 514 44

Abstract:

The present invention relates to a human type-5 recombinant adenovirus vector for achieving cardiac restricted transcription involving utilization of the cardiomyocyte-restricted cardiac ankyrin repeat protein (CARP) promoter with inclusion of the inverted terminal repeat sequences from human adeno-associated virus (AAV). Using green fluorescent protein (GFP) as a marker gene, the recombinant adenovirus vector (Ad/CG/ITR) is shown to direct transgene expression to myocardial tissue in vivo and in vitro in mouse models.

US Patent:

20210161966, Jun 3, 2021

Filed:

Mar 15, 2018

Appl. No.:

16/493573

Inventors:

- Oakland CA, US
Eric Adler - La Jolla CA, US
Sylvia Evans - La Jolla CA, US

International Classification:

A61K 35/28
A61P 3/00
A61K 35/14
C12N 15/86
C07K 14/705

Abstract:

Provided herein are methods for treating a lysosomal transmembrane protein disease or disorder through ex vivo introduction of a nucleic acid molecule into hematopoietic stem and progenitor cells (HSPCs) followed by transplantation of the HSPCs into a subject in need of treatment. Also provided are vectors containing the nucleic acid molecule.