Suzanne C Winters

US Patent:

53387708, Aug 16, 1994

Filed:

Apr 12, 1990

Appl. No.:

7/509063

Inventors:

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
JD Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Assignee:

Cardiopulmonics, Inc. - Salt Lake City UT

International Classification:

A01N 100
A61M 2500

US Classification:

523112

Abstract:

The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface.

US Patent:

52624510, Nov 16, 1993

Filed:

Jul 5, 1988

Appl. No.:

7/215014

Inventors:

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Assignee:

Cardiopulmonics, Inc. - Salt Lake City UT

International Classification:

A01N 100

US Classification:

523112

Abstract:

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.

US Patent:

53426932, Aug 30, 1994

Filed:

Mar 22, 1993

Appl. No.:

8/035426

Inventors:

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Assignee:

Cardiopulmonics, Inc. - Salt Lake City UT

International Classification:

B32B 2706
A01N 100

US Classification:

428447

Abstract:

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.

US Patent:

51823179, Jan 26, 1993

Filed:

Jun 17, 1991

Appl. No.:

7/716843

Inventors:

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Assignee:

Cardiopulmonics, Inc. - Salt Lake City UT

International Classification:

A01N 100

US Classification:

523112

Abstract:

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.