Suzanne M Minshall

US Patent:

20030082136, May 1, 2003

Filed:

Oct 30, 2001

Appl. No.:

10/016528

Inventors:

Bill Minshall - Irvine CA, US
Suzanne Minshall - Irvine CA, US
Michael Skotzko - Thousand Oaks CA, US
John Conner - Sherman Oaks CA, US

International Classification:

A61K038/20
A61K031/715
A61K039/00

US Classification:

424/085200, 424/184100, 424/277100, 514/054000

Abstract:

A therapeutic vaccine for the treatment of melanoma, mast cell tumors and sarcoma in mammals. The vaccine preferably comprises at least one allogenic cell line providing at least one, and preferably two or more gangliosides selected from the group consisting of GD-2, GD-3, GM-2, GM-3, GD-1b and GT-1b. At least one cytokine selected from the group consisting of GM-CSF, IL-2, IL-4, and IL-12 and at least one heat shock protein selected from the group consisting of HSP-60, HSP-70 and HSP-90 are added as adjuvants. A bacterial organism may further be added as an adjuvant.