Larry E. Morrison - Glen Ellyn IL, US Susan Jewell - Gurnee IL, US John S. Coon - Oak Park IL, US
Assignee:
Abbott Laboratories - Abbott Park IL Rush University Medical Center - Chicago IL
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The present invention provides methods for identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab. The invention is based on the discovery that certain chromosomal abnormalities can be used to selectively identify cancer patients that are likely to be successfully treated with medication that inhibits the signaling capability of the HER-2 receptor protein or otherwise function similarly to trastuzumab. The invention is based on the use of nucleic acid technology where nucleic acid probes are allowed to hybridize to cell samples and the number of copies of particular genetic regions quantified. The present invention also provides kits and sets of probes for use in identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab.
Methods And Probe Combinations For Detecting Melanoma
Boris Bastian - Mill Valley CA, US Larry Morrison - Glen Ellyn IL, US Susan Jewell - Elmhurst IL, US
Assignee:
REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA ABBOTT LABORATORIES - Abbott Park IL
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.
Methods And Probe Combinations For Detecting Melanoma
Boris Bastian - Mill Valley CA, US Larry E. Morrison - Glen Ellyn IL, US Susan Jewell - Elmhurst IL, US
Assignee:
ABBOTT LABORATORIES - Abbott Park IL THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
C12Q 1/68
US Classification:
435 611
Abstract:
The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.
Methods And Probe Combinations For Detecting Melanoma
- DES PLAINES IL, US - Oakland CA, US Susan Jewell - Elmhurst IL, US
International Classification:
C12Q 1/6886 C12Q 1/6841
Abstract:
The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.
Kathleen Reilly, Gloria Steck, Judith Waier, Barbara Saatkamp
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Susan Jewell
About:
Susan Jewell MD is a physician scientist, researcher, educator, biomedical engineer and selected to be a flight member as a commercial "medical/scientist" astronaut for low earth orbit (LEO)...