Sunil K Agarwal

US Patent:

20060134111, Jun 22, 2006

Filed:

Dec 16, 2005

Appl. No.:

11/303811

Inventors:

Sunil Agarwal - Corte Madera CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/395

US Classification:

424145100

Abstract:

The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such antagonists to treat autoimmune disease in a patient who has failed prior treatment such as treatment with DMARDs or TNFα-inhibitors.

US Patent:

20090238762, Sep 24, 2009

Filed:

Nov 14, 2006

Appl. No.:

11/665525

Inventors:

Mark Totoritis - Rancho Santa Fe CA, US
Timothy Mark Shaw - Hertfordshire, GB
Sunil Agarwal - Corte Madera CA, US
David Yocum - San Mateo CA, US
Ariella Kelman - Hillsborough CA, US

International Classification:

A61K 39/395
A61P 19/02
A61P 37/00
A61B 10/00

US Classification:

424 92, 4241331

Abstract:

Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography. Further provided are articles of manufacture useful for such methods.

US Patent:

58421963, Nov 24, 1998

Filed:

Apr 3, 1996

Appl. No.:

8/626093

Inventors:

Sunil Agarwal - Alameda CA
Vasudha Krishnaswamy - Redwood City CA

Assignee:

Sybase, Inc. - Emeryville CA

International Classification:

G06F 1730

US Classification:

707 2

Abstract:

Database system and methods are described for updating records, such as are commonly used in a relational database environment. Updates are carried out in a manner which allows a substantial portion of the work to be performed in direct mode (when possible), thereby avoiding the inefficiency of re-reading records. In this fashion, a scenario which requires deferred updating can, in accordance with the present invention, be treated mostly as a direct update, with minimal deferred updating. Given a query involving an "unsafe" unique index (i. e. , query includes update to key field), for instance, the present invention provides a method whereby each data row is updated in direct mode. In conjunction with this, the corresponding index row is deleted in direct mode. The system will not insert an index row at this point, however.