Sumana Datta

US Patent:

20120083419, Apr 5, 2012

Filed:

Nov 7, 2008

Appl. No.:

12/291229

Inventors:

Ariel Ruiz i Altaba - Geneva, CH
Sumana Datta - Bryan TX, US
Milton Datta - Atlanta GA, US

International Classification:

C40B 30/04
C12Q 1/68
G01N 33/566
C12N 5/09
C12N 5/071

US Classification:

506 9, 435375, 435 71, 435 611, 435 612

Abstract:

The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis and methods of inhibiting tumor cell growth and proliferation using agents that inhibit the hedgehog and Gli signaling pathway, including agents that inhibit GLI synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of prostate cancer. Methods of treating cancer, including prostate cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.

US Patent:

20060051819, Mar 9, 2006

Filed:

Jun 17, 2005

Appl. No.:

11/156879

Inventors:

Milton Datta - Atlanta GA, US
Sumana Datta - Decatur GA, US
Ariel Altaba - New York NY, US

Assignee:

The Texas A&M University System - College Station TX

International Classification:

G01N 33/574
A61K 48/00

US Classification:

435007230, 514044000

Abstract:

The present invention includes novel compositions, methods and systems for detecting, evaluating and inhibiting the proliferation of prostate cancer cells by detecting and inhibiting the expression and activity of the proteoglycan Perlecan.