Minzhang Chen - Plainsboro NJ Bosco Anthony DSa - Edison NJ William W. Leong - Westfield NJ Tong Gan - North Brunswick NJ George S. K. Wong - Summit NJ Suhan Tang - Edison NJ Christopher Michael Nielsen - Westfield NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D40114
US Classification:
546187, 546186
Abstract:
In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1â-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4â-methyl-1,4â-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.
Preparation Of Rotamer Mixtures Of Pharmaceutical Salts
Minzhang Chen - Plainsboro NJ, US Bosco D'sa - Edison NJ, US William Leong - Westfield NJ, US Suhan Tang - Edison NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D211/54 C07D211/30
US Classification:
546188, 546190
Abstract:
In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
Preparation Of Salts Of 4-[4-[(1R)-[4-(Trifluoromethyl)Phenyl]-2-Methoxyethyl]-(3S)-Methyl-1-Piperazinyl]-4-Methyl-1-[(4,6-Dimethyl-5-Pyrimidinyl)Carbonyl]
Dinesh Gala - East Brunswick NJ, US Andrew J. Goodman - Annandale NJ, US Gary Lee - Oakland CA, US Hongbiao Liao - Edison NJ, US Martin L. Schwartz - Morris Plains NJ, US Suhan Tang - Edison NJ, US David Js Tsai - Warren NJ, US Wenxue Wu - Princeton Junction NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D401/14
US Classification:
544295
Abstract:
In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
Synthesis Of Piperidine And Piperazine Compounds As Ccr5 Antagonists
William Leong - Westfield NJ, US Minzhang Chen - Plainsboro NJ, US Bosco A. D'sa - Edison NJ, US Man Zhu - Clark NJ, US Tong Xiao - Edison NJ, US Xiongwei Shi - Edison NJ, US Suhan Tang - Plainsboro NJ, US Dinesh Gala - East Brunswick NJ, US Andrew J. Goodman - Annandale NJ, US Christopher M. Nielsen - Westfield NJ, US Gary M. Lee - Belmont CA, US Juan A. Gamboa - New York NY, US Andrew D. Jones - Lexington MA, US
David R. Andrews - Maplewood NJ, US Suhan Tang - Plainsboro NJ, US Wenxue Wu - Princeton Junction NJ, US Sami Y. Kalliney - Chatham NJ, US Anantha Sudhakar - Freemont CA, US Christopher Nielsen - Westfield NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 215/20 C07D 215/38
US Classification:
546169, 546170, 560 23
Abstract:
In one embodiment, the present application discloses a process for making the compound of the formula:.
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