Shiv Pillai - Lexington MA, US Cariappa Annaiah - Marlborough MA, US David Forcione - West Peabody MA, US Subhra Chaudhuri - Madison CT, US
International Classification:
A61K039/395 C12Q001/68
US Classification:
424/155100, 435/006000
Abstract:
Particular HLA alleles are found to be associated with human cancer Some HLA alleles are negatively associated with cancer, whereas others show a positive association. This discovery suggests that the immune system plays an important role in the detection and elimination of human tumors. The invention includes methods of determining susceptibility to cancer as well as prognosis. The invention further includes methods of treatment of cancer wherein expression of a particular HLA allele is modulated