Steven L Warner

US Patent:

7312226, Dec 25, 2007

Filed:

Mar 29, 2005

Appl. No.:

11/092168

Inventors:

Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
David J. Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Salt Lake City UT, US
Sridevi Bashyam - Tucson AZ, US
Steven L. Warner - Tucson AZ, US

Assignee:

Arizona Board of Regents on Behalf of The University of Arizona - Tucson AZ
Montigen Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

A61K 31/519
C07D 487/14
A61P 35/00

US Classification:

514267, 544250

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:.

US Patent:

7326712, Feb 5, 2008

Filed:

Oct 14, 2004

Appl. No.:

10/965313

Inventors:

Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
David J. Bearss - Highland UT, US
Hariprasad Vankayalapati - Salt Lake City UT, US
Sridevi Bashyam - Tucson AZ, US
Steven L. Warner - Tucson AZ, US

Assignee:

Arizona Board of Regents on behalf of The University of Arizona - Tucson AZ
Supergen, Inc. - Dublin CA

International Classification:

C07D 471/14
A61K 31/519
A61P 35/04
C07D 239/70
A61K 31/517

US Classification:

514267, 544250, 544283, 544284, 544293, 5142661, 5142662, 51426624

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:.

US Patent:

7326713, Feb 5, 2008

Filed:

Mar 29, 2005

Appl. No.:

11/092809

Inventors:

Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
David J. Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Salt Lake City UT, US
Sridevi Bashyam - Tucson AZ, US
Steven L. Warner - Tucson AZ, US

Assignee:

Arizona board of Regents on Behalf of the University of Arizona - Tucson AZ
Montigen Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

A61K 31/519
C07D 487/14
A61P 35/00

US Classification:

514267, 544250

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:.

US Patent:

7335662, Feb 26, 2008

Filed:

Mar 29, 2005

Appl. No.:

11/092863

Inventors:

Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
David J. Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Salt Lake City UT, US
Sridevi Bashyam - Tucson AZ, US
Steven L. Warner - Tucson AZ, US

Assignee:

Arizona Board of Regents on Behalf of the University of Arizona - Tucson AZ
Montigen Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

A61K 31/519
C07D 487/14
A61P 35/00

US Classification:

514267, 544250

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:.

US Patent:

8552018, Oct 8, 2013

Filed:

Mar 18, 2011

Appl. No.:

13/051790

Inventors:

Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
David J. Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Draper UT, US
Sridevi Bashyam - Bangalore, IN
Steven L. Warner - Sandy UT, US
James Welsh - Oro Valley AZ, US

Assignee:

Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ
Astex Pharmaceutials, Inc. - Dublin CA

International Classification:

A61K 31/519
A61K 31/496
A61P 35/04
C07D 491/14
C07D 471/14
C07D 239/70
A61K 31/517

US Classification:

514267, 544250, 544283, 544284, 544293, 5142661, 5142662, 51426624

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:.

US Patent:

8569511, Oct 29, 2013

Filed:

Mar 31, 2012

Appl. No.:

13/436905

Inventors:

David J. Bearss - Alpine UT, US
Hariprasad Vankayalapati - Draper UT, US
Venkataswamy Sorna - Salt Lake City UT, US
Steven L. Warner - Sandy UT, US
Sunil Sharma - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 31/5377
A61K 31/454
A61K 31/4184
C07D 401/14
C07D 403/04
C07D 413/14

US Classification:

5483051, 5142345, 514322, 514394, 544139, 546199

Abstract:

In one aspect, the invention relates to substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the PDK1 kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions for treating disorders associated with dysfunction of the PDK1 kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20070026398, Feb 1, 2007

Filed:

Mar 3, 2004

Appl. No.:

10/547488

Inventors:

Amanda Farnsworth - Northglenn CO, US
Haiyong Han - Chandler AZ, US
Hariprasad Vankayalapati - Salt Lake City UT, US
Steven Warner - Tucson AZ, US
Daniel Von Hoff - Scottsdale AZ, US
David Bearss - Highland UT, US

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435006000, 435007230

Abstract:

Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.

US Patent:

20080051414, Feb 28, 2008

Filed:

Mar 1, 2007

Appl. No.:

11/680921

Inventors:

Laurence Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
Haiyong Han - Chandler AZ, US
David Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Draper UT, US
Sridevi Bashyam - Bangalore, IN
Ruben Munoz - Chandler AZ, US
Steven Warner - Mesa AZ, US
Kimiko Della Croce - Tucson AZ, US
Daniel Von Hoff - Scottsdale AZ, US
Cory Grand - Salt Lake City UT, US
James Welsh - Oro Valley AZ, US

Assignee:

Arizona Board of Regents on Behalf of The University of Arizona - Tucson AZ
SuperGen,Inc - Dublin CA

International Classification:

A61K 31/496
A61P 35/00
A61P 43/00
C07D 241/04
C07D 401/14
C07D 403/02
C07D 471/04

US Classification:

514252170, 514252120, 514252140, 514252160, 544250000, 544284000, 544295000, 544358000

Abstract:

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R, R, R, X, Z, L, Cycl, Land Cyclare as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

Author:

Steven B. Warner

ISBN #:

0024245410

Author:

Steven B. Warner

ISBN #:

0072445521

Author:

Steven B. Warner

ISBN #:

0075618370

Author:

Steven D. Warner

ISBN #:

0917724119