Steven B Silbering

US Patent:

7256216, Aug 14, 2007

Filed:

Jun 24, 2003

Appl. No.:

10/602215

Inventors:

Neema M. Kulkarni - Randolph NJ, US
Michael Schneider - Denzlingen, DE
Steven B. Silbering - Forest Hills NY, US
Hans Meyer-Wonnay - Emmendingen, DE

International Classification:

A61K 31/195

US Classification:

514561

Abstract:

A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5. 5 to about 7. 0 and additionally a two-component liquid pharmaceutical composition comprising a first component comprising a powder mixture comprising a GABA analog and a solid polyhydric alcohol, and a second component comprising a liquid base are described, as well as methods to prepare the compositions and a method for treating cerebral diseases, including epilepsy, faintness attacks, hypokinesia and cranial traumas, neurodegenerative disorders, depression, mania and bipolar disorders, anxiety, panic, inflammation, renal colic, insomnia, gastrointestinal damage, incontinence, pain, including neuropathic pain, muscular pain, skeletal pain, and migraine using a therapeutically effective amount of the pharmaceutical compositions.

US Patent:

20020198261, Dec 26, 2002

Filed:

May 28, 2002

Appl. No.:

10/156213

Inventors:

Neema Kulkarni - Randolph NJ, US
Michael Schneider - Denzlingen, DE
Steven Silbering - Forest Hills NY, US
Hans Meyer-Wonnay - Emmendingen, DE

International Classification:

A61K031/195
A61K031/045

US Classification:

514/561000, 514/738000

Abstract:

A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5.5 to about 7.0 and additionally a two-component liquid pharmaceutical composition comprising a first component comprising a powder mixture comprising a GABA analog and a solid polyhydric alcohol, and a second component comprising a liquid base are described, as well as methods to prepare the compositions and a method for treating cerebral diseases, including epilepsy, faintness attacks, hypokinesia and cranial traumas, neurodegenerative disorders, depression, mania and bipolar disorders, anxiety, panic, inflammation, renal colic, insomnia, gastrointestinal damage, incontinence, pain, including neuropathic pain, muscular pain, skeletal pain, and migraine using a therapeutically effective amount of the pharmaceutical compositions.

US Patent:

44774281, Oct 16, 1984

Filed:

Aug 26, 1982

Appl. No.:

6/412041

Inventors:

Steven B. Silbering - Plainsboro NJ
Tibor Sipos - Lebanon NJ

Assignee:

Johnson & Johnson Products, Inc. - New Brunswick NJ

International Classification:

A61K 722
C07C12912

US Classification:

424 52

Abstract:

Oral hygiene formulations incorporating N. sup. alpha. ,N. sup. G -diacyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

US Patent:

44774290, Oct 16, 1984

Filed:

Aug 26, 1982

Appl. No.:

6/412331

Inventors:

Steven B. Silbering - Plainsboro NJ
Tibor Sipos - Lebanon NJ

Assignee:

Johnson & Johnson Products, Inc. - New Brunswick NJ

International Classification:

A61K 722
C07C12912

US Classification:

424 52

Abstract:

Oral hygiene formulations incorporating N. sup. alpha. -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

US Patent:

46968121, Sep 29, 1987

Filed:

Oct 28, 1985

Appl. No.:

6/791836

Inventors:

Steven B. Silbering - Forest Hills NY
Russell U. Nesbitt - Somerville NJ
Mahdi B. Fawzi - Flanders NJ

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 970
A61K 3748
A61L 1500

US Classification:

424445

Abstract:

Thrombin solutions can be rendered storage stable using stabilizing quantities of an anti-autolytic buffer in combination with low levels of saline and glycerol to prevent denaturation.

US Patent:

44990685, Feb 12, 1985

Filed:

Aug 26, 1982

Appl. No.:

6/412365

Inventors:

Steven B. Silbering - Plainsboro NJ
Tibor Sipos - Lebanon NJ

Assignee:

Johnson & Johnson Products, Inc. - New Brunswick NJ

International Classification:

C07C12912
A61K 718
A61K 722

US Classification:

424 52

Abstract:

Oral hygiene formulations incorporating N. sup. G -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

US Patent:

44990677, Feb 12, 1985

Filed:

Aug 26, 1982

Appl. No.:

6/412048

Inventors:

Steven B. Silbering - Plainsboro NJ
Tibor Sipos - Lebanon NJ

Assignee:

Johnson & Johnson Products, Inc. - New Brunswick NJ

International Classification:

C07C12912
A61K 718
A61K 722

US Classification:

424 52

Abstract:

Oral hygiene formulations incorporating N. sup. G -acyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

US Patent:

49652036, Oct 23, 1990

Filed:

Jun 13, 1989

Appl. No.:

7/365470

Inventors:

Steven B. Silbering - Forest Hills NY
Rowland P. Blythe - Washington MI
Russell U. Nesbitt - Somerville NJ
Mahdi B. Fawzi - Flanders NJ

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C12N 996
C12N 974
A61F 1300
A61K 37547

US Classification:

435188

Abstract:

Improved thrombin formulations, stable at room temperature using stabilizing quantities of a polyol and a buffer at specific pHs are described wherein crude thrombin is first purified by two-stage ion exchange chromatography.