Steven L Regen

US Patent:

20020002207, Jan 3, 2002

Filed:

Jan 26, 2001

Appl. No.:

09/771367

Inventors:

Steven Regen - Allentown PA, US

International Classification:

C08J005/20
C08F002/00
C02F001/42

US Classification:

521/032000, 210/683000

Abstract:

There is described a group of underquarternized anion exchange resins having the ability to bind with and remove from one environment to another a significant fraction of scavenged molecules by forming covalent bonds with the molecules. The method of using such underquarternized resins is also described.

US Patent:

20050028670, Feb 10, 2005

Filed:

Jun 8, 2004

Appl. No.:

10/862574

Inventors:

Steven Regen - Allentown PA, US

International Classification:

B01D053/22

US Classification:

095045000

Abstract:

The present invention relates to a Langmuir-Blodgett (LB) thin film, which includes: at least one molecular layer, which includes one or more monolayer-forming surfactant molecules having a first ionic charge, ionically cross-linked with at least one water-soluble agent having a second ionic charge; wherein a total amount of the first and second charges is at least 5; and wherein each of the first and second charges is independently 2 or greater. The present invention also relates to novel polymerizable surfactant compounds as well as articles and methods using the thin film, and methods of making the thin film.

US Patent:

20070232576, Oct 4, 2007

Filed:

Sep 20, 2005

Appl. No.:

11/230806

Inventors:

Steven Regen - Allentown PA, US
Betsy Herold - Scarsdale NY, US

Assignee:

Lehigh University - Bethlehem PA
Mount Sinai School of Medicine of New York University - New York NY

International Classification:

A61K 31/56
C07J 1/00

US Classification:

514169000, 552509000

Abstract:

A chemical genus of sulfated cholestanes attached to an oligomer through amide or ester bonds is disclosed. The compounds are useful as anti human immunodeficiency virus (HIV) and anti-herpes simplex virus (HSV) agents. The compounds have the general formula in which CPS (the structure within the square brackets) is a cholanic acid derivative. Rto Rare chosen independently from H, OH and OSOA. W is a direct bond or a deshydrogen residue of a C3-C6 diol or triol. A is chosen from H, a quaternary ammonium species and the cation of an alkali or alkaline earth metal. Z is a direct bond or a residue of an amino acid, a peptide or an aminosulfonic acid. Ω is a moiety having n or more —NH and —OH groups separated by 6 or fewer carbons; and n is an integer from 6 to 200.

US Patent:

20110065672, Mar 17, 2011

Filed:

Sep 16, 2010

Appl. No.:

12/883662

Inventors:

ALEXANDER KIRSCHENBAUM - NEW YORK NY, US
ALICE C. LEVINE - NEW YORK NY, US
STEVEN L. REGEN - ALLENTOWN PA, US
VACLAV JANOUT - BETHLEHEM PA, US

Assignee:

MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY - NEW YORK NY
LEHIGH UNIVERSITY - BETHLEHEM PA

International Classification:

A61K 31/664
C07F 9/44
A61P 35/00

US Classification:

514108, 558155

Abstract:

The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

US Patent:

20140045797, Feb 13, 2014

Filed:

Oct 16, 2013

Appl. No.:

14/055313

Inventors:

STEVEN L. REGEN - Allentown PA, US
VACLAV JANOUT - Bethlehem PA, US

Assignee:

LEHIGH UNIVERSITY - Bethlehem PA
MOUNT SINAI SCHOOL OF MEDICINE - New York NY

International Classification:

A61K 47/48

US Classification:

514101, 514108

Abstract:

The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

US Patent:

44850450, Nov 27, 1984

Filed:

May 26, 1982

Appl. No.:

6/382296

Inventors:

Steven L. Regen - Milwaukee WI

Assignee:

Research Corporation - Tucson AZ

International Classification:

A23J 700
C07F 910

US Classification:

260403

Abstract:

Lower-. omega. -alkenoyloxy-long chain alkanoic anhydrides are synthesized from the. omega. -hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.

US Patent:

58344535, Nov 10, 1998

Filed:

Jun 17, 1997

Appl. No.:

8/877618

Inventors:

Steven L. Regen - Allentown PA

Assignee:

Lehigh University - Bethlehem PA

International Classification:

A61K 3156

US Classification:

514182

Abstract:

A method of forming a pharmaceutical composition of antimicrobial sterol conjugates having the following formulae: ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 and Y are as defined in the specification. Also disclosed is a method of inducing an antimicrobial effect by administrating these pharmaceutical compositions.

US Patent:

51791900, Jan 12, 1993

Filed:

Mar 16, 1990

Appl. No.:

7/494422

Inventors:

Steven L. Regen - Bethlehem PA

International Classification:

C08G 6302

US Classification:

528272

Abstract:

An amphiphilic polymer, having the monomer unit structure A, B, C, or D: ##STR1## wherein R is at least one H and C. sub. 1-6 alkyl, k=1-4, m=4-30, n=2-50 and x=2-500. ##STR2## wherein p and q are, independently, 0-22, and the sum of p and q is 4-22; ##STR3## wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds A, B, C and D is replaced by an amide, urea, urethane, ether or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.