Steven A Mccarroll

US Patent:

20070172853, Jul 26, 2007

Filed:

Dec 4, 2006

Appl. No.:

11/633336

Inventors:

Steven McCarroll - Cambridge MA, US
David Altshuler - Brookline MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

Disclosed herein are methods for predicting the immunocompatibility of two subjects that include determining the presence or absence of one or more deletion variants in the DNA sequence of a gene, where the deletion variant substantially prevents expression of the protein encoded by the gene.

US Patent:

20220348590, Nov 3, 2022

Filed:

Sep 10, 2020

Appl. No.:

17/642662

Inventors:

- Cambridge MA, US
- Boston MA, US
Antoine Bigot - Cambridge MA, US
Agathe Fayet - Cambridge MA, US
Besnik Bajrami - Cambridge MA, US
Jacob Hooker - Boston MA, US
Michael Placzek - Boston MA, US
Beth A. Stevens - Boston MA, US
Daniel Wilton - Boston MA, US
Steven McCarroll - Cambridge MA, US

Assignee:

The Board Institute, Inc. - Cambridge MA
The General Hospital Corporation - Boston MA
Children's Medical Center Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D 491/048
C07D 409/12
C07D 405/12
C07D 213/34
C07D 405/06
C07D 409/14
C07D 241/20
C07D 409/06
C07D 213/64
C07D 401/12
C07D 417/12
C07D 405/08
C07D 241/18
C07D 413/12
C07D 213/74
C07D 241/26
C07D 471/04
C07D 473/00
C07D 333/20
C07D 239/34
C07D 239/42
C07D 487/04
C07D 295/00

Abstract:

The present disclosure describes compounds of the formula: (I), (II), (III), (IV), (V). The compounds described herein may be cyclooxygenase (COX) (e.g., cyclooxygenase 2 (COX2)) inhibitors. The compounds may be radiolabeled. The compounds (e.g., radiolabeled compounds) may be useful (e.g., as positron emission tomography (PET) imaging agents) for diagnosing a disease. The compounds may also be useful for treating or preventing a disease. The present disclosure also describes pharmaceutical compositions and kits including the compounds; and methods of using the compounds.

US Patent:

20200303036, Sep 24, 2020

Filed:

Oct 17, 2018

Appl. No.:

16/757329

Inventors:

- Cambridge MA, US
Steven McCarroll - Cambridge MA, US

International Classification:

G16B 20/10
G16B 20/20
G16B 5/00
G16H 10/40

Abstract:

Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.