David F. Woodward - Lake Forest CA Helen H. Usansky - Irvine CA Steven W. Andrews - Rancho Santa Margarita CA Robert M. Burk - Laguna Beach CA June Chen - San Juan Capistrano CA Achim H-P. Krauss - Foothill Ranch CA
Assignee:
Allergan Sales, Inc. - Irvine CA
International Classification:
A61K 315575
US Classification:
514613, 514622, 564171, 564189
Abstract:
Compounds of Formula 1, where the symbols are as defined in the specification, are useful as ocular hypotensive agents but do not exert their activity through the FP prostaglandin receptor. In particular the compound PGF 1-ethanolamide, having the formula was discovered to be present in mammalian tissue as a naturally occurring substance, was synthesized in a substantially pure form and was found to be effective for lowering intraocular pressure in the mammalian eye, but not acting through the FP receptor through which many ocular hypotensive prostaglandins act.
(3Z)-3-(2,3-Dihydro-1H-Inden-1-Ylidene)-1,3-Dihydro-2H-Indol-2-Ones As Kinase Inhibitors
Steven W. Andrews - Longmont CO Julie A. Wurster - Irvine CA Edward H. Wang - Dove Canyon CA Thomas Malone - Irvine CA Xialing Guo - Irvine CA Zhen Zhu - Tustin CA
Assignee:
Allergan Sales, LLC - Irvine CA
International Classification:
A61K 31404
US Classification:
514414, 548464
Abstract:
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
3-(Heteroarylamino)Methylene-1,3-Dihydro-2H-Indol-2-Ones As Kinase Inhibitors
Steven W. Andrews - Longmont CO Julie A. Wurster - Irvine CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 314152
US Classification:
514404, 5483647
Abstract:
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
Steven W. Andrews - Longmont CO Michael E. Garst - Newport Beach CA Xialing Guo - Irvine CA Jonathan J. Hebert - Carlsbad CA Thomas Malone - Irvine CA Julie A. Wurster - Irvine CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 315355
US Classification:
5142352, 544129, 544144
Abstract:
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell poliferation.
3-(Arylamino)Methylene-1,3-Dihydro-2H-Indol-2-Ones As Kinase Inhibitors
Steven W. Andrews - Longmont CO Julie A. Wurster - Irvine CA Edward H. Wang - Dove Canyon CA Thomas Malone - Irvine CA
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31435
US Classification:
514323, 514414, 514418, 546201, 548467, 548486
Abstract:
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
3-(Heteroarylamino)Methylene-1, 3-Dihydro-2H-Indol-2-Ones As Kinase Inhibitors
Steven W. Andrews - Longmont CO, US Julie A. Wurster - Irvine CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31/4155 C07D 403/12
US Classification:
514407, 5483647
Abstract:
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
3-(Arylamino)Methylene-1, 3-Dihydro-2H-Indol-2-Ones As Kinase Inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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ISLN:
909420541
Admitted:
1978
University:
Florida State University, B.S., 1975; New York University, 1979
Associate Director, Drug Discovey at Array BioPharma
Location:
Greater Denver Area
Industry:
Biotechnology
Work:
Array BioPharma since Aug 2001
Associate Director, Drug Discovey
Allergan Jul 1991 - Jul 2001
Principle Scientist
Education:
University of Colorado at Boulder 1984 - 1989
Ph.D., Synthetic Chemistry
University of California, Irvine 1980 - 1984
B.S., Chemistry
University of Rochester
Post Doc, Synthetic Chemistry
Skills:
Drug Discovery Drug Metabolism ADME Medicinal Chemistry DMPK Drug Development Pharmacokinetics LC-MS
port and recommendation from Roberts as to whether Artiles violated Senate rules and whether he should be removed from office is expected Tuesday. But the Associated Press' Brendan Farrington reports that Artiles hadhired lawyer Steven Andrews, whose reputation as a pitbull greatly proceeds him. Th
Date: Apr 21, 2017
Category: U.S.
Source: Google
Beijing releases key data expected to indicate extent of its air pollution
Steven Andrews, an environmental consultant who has studied Beijings pollution data since 2006, said he was already a bit suspicious of Beijings PM2.5 data. Within the 24-hour period to noon Saturday, Beijing reported seven hourly figures at the very low level of 0.003 milligrams per cubic met