Michael Weiner - Guilford CT, US Said Attiya - Branford CT, US Hugh Crenshaw - Durham NC, US Jonathan Rothberg - Guilford CT, US Stephen Matson - Harvard MA, US
International Classification:
C12Q001/68 C12M001/34
US Classification:
435006000, 435287200
Abstract:
The present invention relates to the field of fluid dynamics. More specifically, this invention relates to methods and apparatus for conducting densely packed, independent chemical reactions in parallel in a substantially two-dimensional array. Accordingly, this invention also focuses on the use of this array for applications such as DNA sequencing, most preferably pyrosequencing, and DNA amplification.
Stephen A. Wald - Wayland MA Stephen L. Matson - Harvard MA Charles M. Zepp - Berlin MA David R. Dodds - Millis MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
C12P 762
US Classification:
435280
Abstract:
This invention relates to a novel method of effecting aqueous enzymatic and homogeneous resolutions of racemic esters which exhibit enhanced aqueous solubility. The preferred embodiment of this invention relates to the resolutions which are effected by placing the enzyme and racemic esters in an aqueous phase wherein one of the ester enantiomers is preferentially and stereospecifically de-esterified to effect the resolution of the initial racemic mixture. In another embodiment of this invention, the resolutions are effected by placing the enzyme and racemic esters in an aqueous phase, and contacting this aqueous phase with an organic phase. The preferential and stereospecific de-esterification of one of the ester enantiomers is effected, and the chiral acid product of the de-esterification reaction is extracted into the organic phase.
Production Of Low-Ethanol Beverage By Membrane Extraction
Eric K. L. Lee - Acton MA Vinay J. Kalyani - Chelmsford MA Stephen L. Matson - Harvard MA
International Classification:
B01D 6136 B01D 6302
US Classification:
2103218
Abstract:
Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.
Production Of Low-Ethanol Beverage By Membrane Extraction
Eric K. L. Lee - Acton MA Vinay J. Kalyani - Chelmsford MA Stephen L. Matson - Harvard MA
International Classification:
C12G 300
US Classification:
426319
Abstract:
Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.
Antipyretic And Analgesic Methods Using Optically Pure R-Ketorolac
Timothy J. Barberich - Concord MA Stephen L. Matson - Harvard MA William J. Wechter - Redlands CA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 3140
US Classification:
514413
Abstract:
Methods are disclosed utilizing optically pure R-ketorolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain (e. g. , after periodontal surgery) and ophthalmic pain (e. g. , after cataract surgery) while avoiding adverse effects which are associated with the administration of the racemic mixture of ketorolac. The optically pure R-ketorolac is also useful in treating pyrexia while avoiding the adverse effects associated with the administration of the racemic mixture of ketorolac.
Process Of Treating Alcoholic Beverages By Vapor-Arbitrated Pervaporation
Eric K. Lee - Acton MA Vinay J. Kalyani - Tewksbury MA Stephen L. Matson - Harvard MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
B01D 6136
US Classification:
55158
Abstract:
The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.
Process Of Treating Alcoholic Beverages By Vapor-Arbitrated Pervaporation
Eric K. Lee - Acton MA Vinay J. Kalyani - Tewksbury MA Stephen L. Matson - Harvard MA
Assignee:
Sepracor - Marlbrough MA
International Classification:
B01D 6136
US Classification:
210640
Abstract:
The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.
Name / Title
Company / Classification
Phones & Addresses
Stephen C. Matson
MATSON INSURANCE AGENCY, INC
Stephen Matson Secondary Guidance Counselor
East Granby Public Schools Elementary/Secondary School
33 Turkey Hl Rd, East Granby, CT 06026 860 653-2505