Stephan A Kraemer

US Patent:

7855054, Dec 21, 2010

Filed:

Jul 17, 2008

Appl. No.:

12/175446

Inventors:

Daniel J. Schneider - Arvada CO, US
Dan Nieuwlandt - Longmont CO, US
Bruce Eaton - Longmont CO, US
Marty Stanton - Boulder CO, US
Shashi Gupta - Louisville CO, US
Stephan Kraemer - Boulder CO, US
Dominic Zichi - Boulder CO, US
Larry Gold - Boulder CO, US

Assignee:

SomaLogic, Inc. - Boulder CO

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04
C12P 19/34

US Classification:

435 6, 536 231, 536 243

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e. g. , a protein target) in a test sample by detecting and quantifying a nucleic acid (i. e. , an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

US Patent:

20110136099, Jun 9, 2011

Filed:

Dec 2, 2010

Appl. No.:

12/958620

Inventors:

Daniel J. Schneider - Arvada CO, US
Dan Nieuwlandt - Longmont CO, US
Bruce Eaton - Longmont CO, US
Marty Stanton - Boulder CO, US
Shashi Gupta - Louisville CO, US
Stephan Kraemer - Boulder CO, US
Dominic Zichi - Boulder CO, US
Larry Gold - Boulder CO, US

Assignee:

SOMALOGIC, INC. - Boulder CO

International Classification:

G01N 33/53
G01N 33/543
C12Q 1/68
C12Q 1/70
G01N 33/567
G01N 33/545
G01N 33/544
G01N 33/553
G01N 33/552

US Classification:

435 5, 436518, 435 612, 435 79, 435 721, 436531, 436529, 436526, 436527, 436525

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

US Patent:

20210239692, Aug 5, 2021

Filed:

Mar 30, 2021

Appl. No.:

17/217006

Inventors:

- Boulder CO, US
Stephan Kraemer - Boulder CO, US
Evaldas Katilius - Superior CO, US
EDGAR OLIVAS - Westminster CO, US

International Classification:

G01N 33/543
C12Q 1/6811
C07H 21/00
G01N 33/53
G01N 33/68
C12Q 1/6804
C12Q 1/6837

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

US Patent:

20180224444, Aug 9, 2018

Filed:

Nov 30, 2017

Appl. No.:

15/827441

Inventors:

- Boulder CO, US
Stephan Kraemer - Boulder CO, US
Evaldas Katilius - Superior CO, US

International Classification:

G01N 33/543
G01N 33/68
C07H 21/00
G01N 33/53
C12Q 1/6811

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

US Patent:

20170176422, Jun 22, 2017

Filed:

Mar 9, 2017

Appl. No.:

15/454080

Inventors:

- Boulder CO, US
Stephan Kraemer - Boulder CO, US
Evaldas Katilius - Superior CO, US

International Classification:

G01N 33/53
C12Q 1/68
G01N 33/68
G01N 33/543

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

US Patent:

20150158029, Jun 11, 2015

Filed:

Dec 1, 2014

Appl. No.:

14/557183

Inventors:

- Boulder CO, US
Alexis Stuart Foreman - Boulder CO, US
Tracy R. Keeney - Firestone CO, US
Jonathan Vaught - Boulder CO, US
Chris Bock - Denver CO, US
Stephan Kraemer - Boulder CO, US

International Classification:

B01L 9/00
B25B 11/00
B01L 99/00
B01L 9/02

Abstract:

Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.

US Patent:

20150141259, May 21, 2015

Filed:

Jun 7, 2013

Appl. No.:

14/401791

Inventors:

- Boulder CO, US
Stephan Kraemer - Boulder CO, US
Evaldas Katilius - Superior CO, US

International Classification:

G01N 33/543
G01N 33/68

US Classification:

506 2, 435 61, 506 9, 436501, 435 5, 506 16, 435 612

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

US Patent:

20140249043, Sep 4, 2014

Filed:

Feb 10, 2014

Appl. No.:

14/176933

Inventors:

- Boulder CO, US
Dan Nieuwlandt - Longmont CO, US
Bruce Eaton - Longmont CO, US
Martin Stanton - Boulder CO, US
Shashi Gupta - Louisville CO, US
Stephan Kraemer - Boulder CO, US
Dominic Zichi - Boulder CO, US
Larry Gold - Boulder CO, US

Assignee:

SOMALOGIC, INC. - Boulder CO

International Classification:

G01N 33/53
G01N 33/74
G01N 33/68
G01N 33/543

US Classification:

506 9, 436501, 435 611, 435 612, 435 61, 435 5

Abstract:

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.