Stephen J Cripps

US Patent:

6635641, Oct 21, 2003

Filed:

Jan 19, 2001

Appl. No.:

09/764306

Inventors:

Steven Lee Bender - Oceanside CA
Dilip Bhumralkar - San Diego CA
Michael Raymond Collins - San Diego CA
Stephen James Cripps - San Diego CA
Judith Gail Deal - Wildomar CA
Lei Jia - San Diego CA
Mitchell David Nambu - San Diego CA
Cynthia Louise Palmer - La Mesa CA
Zhengwei Peng - San Diego CA
Michael David Varney - Solana Beach CA

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07D24118

US Classification:

514247, 544224, 544238, 544408, 544410, 544236, 544237, 544353, 544354, 51425201, 514248, 51425505, 5142521, 5482632, 5483661, 548375, 546139, 546141, 546153, 546181, 546329, 546339, 546345, 546118, 546119

Abstract:

Amide compounds represented by the formula: wherein: R is a moiety represented by the formula âwhere X is selected from the group consisting of CH , O, S, and NH; and Y is selected from the group consisting of CH , O, and S, provided that at least one of X and Y is CH , or X and Y together with the bond there-between form a cyclopropyl; are described. These compounds and pharmaceutical compositions containing them modulate and/or inhibit the activity of certain protein kinases and are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

US Patent:

20040092747, May 13, 2004

Filed:

Jul 17, 2003

Appl. No.:

10/621979

Inventors:

Steven Bender - Oceanside CA, US
Michael Collins - San Diego CA, US
Stephen Cripps - San Diego CA, US
Judith Deal - Wildomar CA, US
Lei Jia - San Diego CA, US
Mitchell Nambu - San Diego CA, US
Cynthia Palmer - La Mesa CA, US
Zhengwei Peng - San Diego CA, US
Michael Varney - Solana Beach CA, US

International Classification:

C07D271/12
C07D285/14
C07D249/08

US Classification:

548/131000, 548/136000, 548/262200

Abstract:

Amide compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.