Sri K Tummala

US Patent:

20190202797, Jul 4, 2019

Filed:

Mar 11, 2019

Appl. No.:

16/298355

Inventors:

- Silver Spring MD, US
Sudersan M. Tuladhar - Silver Spring MD, US
Sri Harsha Tummala - Owings Mills MD, US
Raju Penmasta - Herndon VA, US
David A. Walsh - Spotsylvania VA, US

Assignee:

Lung Biotechnology PBC - Silver Spring MD

International Classification:

C07D 307/93
C07C 67/307
C07C 233/20
C07C 67/00
C07C 69/65

Abstract:

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

US Patent:

20180265490, Sep 20, 2018

Filed:

May 4, 2018

Appl. No.:

15/971132

Inventors:

- Silver Spring MD, US
Sudersan M. Tuladhar - Silver Spring MD, US
Sri Tummala - Owings Mills MD, US
Raju Penmasta - Herndon VA, US
David A. Walsh - Spotsylvania VA, US

Assignee:

Lung Biotechnology PBC - Silver Spring MD

International Classification:

C07D 307/93
C07C 67/00
C07C 233/20
C07C 69/65
C07C 67/307

Abstract:

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

US Patent:

20170166545, Jun 15, 2017

Filed:

May 19, 2015

Appl. No.:

15/312295

Inventors:

- Silver Spring MD, US
Sudersan M. Tuladhar - Silver Spring MD, US
Sri Harsha Tummala - Owings Mills MD, US
Raju Penmasta - Herndon VA, US
David A. Walsh - Spotsylvania VA, US

Assignee:

Lung Biotechnology PBC - Silver Spring MD

International Classification:

C07D 307/93
C07C 67/00
C07C 67/307
C07C 69/65
C07C 233/20

Abstract:

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.