Simeng M Suy from 2550 24Th St, Arlington, VA 22207, age 57, Phone: 703 273-3030

Us Patents

Compositions And Methods For Inducing Cell Death
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US Patent:

20040024025, Feb 5, 2004
Filed:

Mar 13, 2003
Appl. No.:

10/382317
Inventors:

Usha Kasid - Rockville MD, US
Simeng Suy - Richmond VA, US
Assignee:

Georgetown University
International Classification:

A61K031/454
A61K031/445
US Classification:

514/326000
Abstract:

A method is provided for inducing cell death comprising administering to said cell a composition comprising tempo or a functional derivative of tempo.

Gene Shinc-1 And Diagnostic And Therapeutic Uses Thereof
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US Patent:

20040161775, Aug 19, 2004
Filed:

Oct 6, 2003
Appl. No.:

10/680313
Inventors:

Usha Kasid - Rockville MD, US
Isamu Sakabe - Washington DC, US
Simeng Suy - Richmond VA, US
Deepak Kumar - Arlington VA, US
Imran Ahmad - Wadsworth IL, US
International Classification:

C12Q001/68
G01N033/574
C07H021/04
US Classification:

435/006000, 435/007230, 435/069100, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:

The partial DNA sequence of new gene SHINC-1 is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SHINC-1 such as breast cancer, leukemia, lymphoma, melanoma, colorectal cancer, and lung cancer.

Na Channels, Disease, And Related Assays And Compositions
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US Patent:

20110230442, Sep 22, 2011
Filed:

Aug 17, 2009
Appl. No.:

13/059182
Inventors:

Milton L. Brown - Brookeville MD, US
Scott Grindrod - Arlington VA, US
Thomas H. Walls - Arlington VA, US
Todd Hansen - Norfolk VA, US
Simeng Suy - Fairfax VA, US
Mikell A. Paige - Fairfax VA, US
Assignee:

GEORGETOWN UNIVERSITY - WASHINGTON DC
International Classification:

A61K 31/69
C07D 233/76
C07F 5/02
A61K 31/4166
C12Q 1/02
C07C 231/10
C07D 209/14
C07C 231/02
G01N 33/574
C12N 5/07
G01N 21/00
C12Q 1/68
A61P 25/08
A61P 35/00
US Classification:

514 64, 5483191, 548405, 514391, 435 29, 554112, 548507, 564123, 435 723, 435325, 436172, 435 611
Abstract:

Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [H]-Batrachotoxin-B ([H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.