Silvina M Bocca

US Patent:

20090215085, Aug 27, 2009

Filed:

Jan 29, 2007

Appl. No.:

12/162471

Inventors:

Sergio C. Oehninger - Norfolk VA, US
O. John Semmes - Newport News VA, US
Lisa H. Cazares - Chesapeake VA, US
Silvina Bocca - Norfolk VA, US

Assignee:

Eastern Virginia Medical School - Norfolk VA

International Classification:

G01N 33/53
C12Q 1/02
C12M 1/00
B01D 59/44

US Classification:

435 721, 435 29, 4352872, 250282

Abstract:

The present invention discloses biomarkers and biomarker combinations that have prognostic value as predictors of the developmental potential of individual IVF-derived human embryos. In particular, the biomarkers of this invention are useful to classify an embryo with implantation competence after uterine transfer or implantation incompetence. In addition, the biomarkers can be detected by non-invasive methods that do not harm the developing embryo. Also disclosed are kits for the prediction of developmental potential that detect the biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of developmental potential.