Shuo Yang

US Patent:

20150064255, Mar 5, 2015

Filed:

Feb 22, 2013

Appl. No.:

14/380406

Inventors:

- Evanston IL, US
Marina G. Damiano - Chicago IL, US
Heng Zhang - Chicago IL, US
Kaylin M. McMahon - Chicago IL, US
Shuo Yang - Lisle IL, US
Leo I. Gordon - Winnetka IL, US
Amareshwar T.K. Singh - Buffalo Grove IL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

A61K 9/14
A61K 47/02
A61K 38/17

US Classification:

424489, 424400, 514 74, 435375

Abstract:

Nanostructures, compositions and methods for treating cancers and other conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers or other diseases or conditions at least in part by controlling cholesterol metabolism in cells. The nanostructures and compositions may be used, for example, to control cholesterol influx and/or efflux in cells. In some cases, the nanostructures or compositions may be used to kill the cells. Examples of cancer cells that may be affected by the nanostructures and compositions described herein include those having scavenger receptor type B-I (SR-B1), B-cell lymphoma cells, non-Hodgkin's lymphoma cells, melanoma cells and/or others. In some embodiments, the nanostructures may be mimics of natural high-density lipoprotein (HDL).