Shirley Shi

US Patent:

8029765, Oct 4, 2011

Filed:

Dec 23, 2004

Appl. No.:

10/584821

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8466286, Jun 18, 2013

Filed:

Aug 22, 2011

Appl. No.:

13/215061

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C07F 5/02
A61K 49/00
A61B 5/00
A61B 8/00
A61B 10/00
C07D 471/00

US Classification:

546 13, 546 66, 514288, 514 64, 436 95, 436172, 436164, 424 91, 424 96

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

20100055680, Mar 4, 2010

Filed:

Aug 28, 2008

Appl. No.:

12/199993

Inventors:

Shirley Jufang Shi - Lexington MA, US

Assignee:

PerkinElmer LAS, Inc. - Waltham MA

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 6, 435 912

Abstract:

Methods of amplifying genomic DNA are provided which include contacting template genomic DNA, a plurality of random primers, and a DNA polymerase, wherein the ratio of template genomic DNA to random primers is in the range of about 1:10-1:35,000,000 (w/w), inclusive, to produce a reaction mixture; and incubating the reaction mixture under isothermal conditions suitable for DNA synthesis, thereby producing amplified genomic DNA characterized by less than 10 percent gene copy number error. The template genomic DNA used in described methods can be in denatured condition and/or in non-denatured condition to achieve production of amplified genomic DNA characterized by less than 10 percent gene copy number error. In a particular option, the reaction mixture includes detectably labeled nucleotides and detectably labeled amplified genomic DNA characterized by less than 10 percent gene copy number error is produced.

US Patent:

8008088, Aug 30, 2011

Filed:

Jun 26, 2006

Appl. No.:

11/475784

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

G01N 33/00
A61K 49/00

US Classification:

436 95, 436172, 436164, 436518, 436546, 424 96, 424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

20140127137, May 8, 2014

Filed:

Jun 17, 2013

Appl. No.:

13/919923

Inventors:

- Irvine CA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc - Irvine CA

International Classification:

A61K 49/00
C07F 5/02

US Classification:

424 96, 549213, 546 13, 562 7

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.