Shawn M Swavey

US Patent:

7612057, Nov 3, 2009

Filed:

Jul 20, 2005

Appl. No.:

11/184840

Inventors:

Karen Brewer - Blacksburg VA, US
Shawn Swavey - Kettering OH, US

Assignee:

Virginia Tech Intellectual Properties, Inc. - Blacksburg VA

International Classification:

A61K 31/555
A01N 55/02

US Classification:

514188, 514184

Abstract:

The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e. g. Ru or Os) to an electron accepting metal (e. g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

US Patent:

8445475, May 21, 2013

Filed:

Nov 2, 2009

Appl. No.:

12/610729

Inventors:

Karen Brewer - Blacksburg VA, US
Shawn Swavey - Springboro OH, US

Assignee:

Virginia Tech Intellectual Properties, Inc. - Blacksburg VA

International Classification:

A61K 31/555
A01N 55/02

US Classification:

514184, 514188

Abstract:

The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e. g. Ru or Os) to an electron accepting metal (e. g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

US Patent:

20030180767, Sep 25, 2003

Filed:

Jan 31, 2003

Appl. No.:

10/355258

Inventors:

Karen Brewer - Blacksburg VA, US
Shawn Swavey - Kettering OH, US

International Classification:

C12Q001/68
C07H021/04
C07F015/00

US Classification:

435/006000, 536/023100, 544/225000

Abstract:

The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging -acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

US Patent:

20160051676, Feb 25, 2016

Filed:

Aug 22, 2014

Appl. No.:

14/466662

Inventors:

Jayne B. Robinson - Dayton OH, US
Shawn Swavey - Springboro OH, US

Assignee:

UNIVERSITY OF DAYTON - Dayton OH

International Classification:

A61K 41/00
A61L 2/08
A61N 5/06
A01N 43/90

Abstract:

A porphyrin of general formula (I) having a transition metal (II) cation in its core and one or two mono-, di-, tri-, tetra- or penta-halophenyl groups and two or three pyridyl groups in the 5, 10, and/or 15 positions of the porphyrin ring contributing to a positive two or three charge neutralized by the presence of a respective number of anions. The porphyrin of the general formula (I) characterized by killing bacteria in the dark.