Shan C Jiang

US Patent:

6960434, Nov 1, 2005

Filed:

May 22, 2001

Appl. No.:

09/861893

Inventors:

Andrew P. Feinberg - Cleveland OH, US
Shan Jiang - Trumbull CT, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12Q001/68
C12P019/34

US Classification:

435 6, 435 911, 435 912

Abstract:

Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8. 5 d. p. c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors.

US Patent:

7488815, Feb 10, 2009

Filed:

Mar 17, 2005

Appl. No.:

11/084085

Inventors:

Andrew P. Feinberg - Cleveland OH, US
Shan Jiang - Trumbull CT, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C07H 21/04

US Classification:

536 241, 536 243

Abstract:

Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8. 5 d. p. c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors.

US Patent:

7985550, Jul 26, 2011

Filed:

Jan 7, 2009

Appl. No.:

12/350159

Inventors:

Andrew P. Feinberg - Cleveland OH, US
Shan Jiang - Trumbull CT, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Provided is a method for isolating methylated CpG islands. The method includes identifying an imprinted gene adjacent to the methylated CpG island, and identifying a disease which is preferentially transmitted by one parent and which is genetically linked to region of genomic DNA which contains the imprinted gene, whereby the imprinted gene is thereby indicated as a candidate gene involved in transmitting the disease.

US Patent:

8648086, Feb 11, 2014

Filed:

Aug 20, 2010

Appl. No.:

12/922527

Inventors:

Shan Jiang - Trumbull CT, US
Xinglong Xing - Suzhou, CN
Qishan Wang - Pleasenton CA, US
Ren Kong - Suzhou, CN

Assignee:

Ascepion Pharmaceuticals, Inc. - Suzhou

International Classification:

A61K 31/52
C07D 513/02

US Classification:

5142631, 514300, 5142651, 546113, 544280

Abstract:

The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met, PDGFRβ c-Kit, CSF1R, or EphA2.

US Patent:

20020087275, Jul 4, 2002

Filed:

Jul 31, 2001

Appl. No.:

09/918938

Inventors:

Junhyong Kim - Hamden CT, US
Shan Jiang - Trumbull CT, US

International Classification:

G01N033/48
G06F019/00

US Classification:

702/019000, 702/027000

Abstract:

A system for analyzing and graphically visualizing biomolecular data, such as genomic data, is provided.

US Patent:

20030174636, Sep 18, 2003

Filed:

May 7, 2003

Appl. No.:

10/276263

Inventors:

Andrew Feinberg - Cleveland OH, US
Shan Jiang - Trumbull CT, US

International Classification:

G11B017/30
G11B021/02
G11B017/00
G11B021/16

US Classification:

369/249000, 369/223000

Abstract:

An optical scanning device () for reading data stored on a rotating recording medium () having a scanning head (); at least one guide device () for guiding the scanning head () along a predefined track; at least one bearing device () connected to the scanning head () for supporting the at least one guide device () and having at least one elastic prestressing device () to provide a static prestress on the at least one guide device () to prestress the same and the at least one bearing device () connected to the scanning head () against each other to eliminate a relative displacement.

US Patent:

20050153440, Jul 14, 2005

Filed:

May 22, 2001

Appl. No.:

10/296263

Inventors:

Andrew Feinberg - Lutherville MD, US
Shan Jiang - Trumbull CT, US

International Classification:

C12N005/06

US Classification:

435354000

Abstract:

Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8.5 d.p.c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors. This approach identifies a methylome of methylated CpG islands throughout the genome.

US Patent:

20130165475, Jun 27, 2013

Filed:

Sep 1, 2011

Appl. No.:

13/817505

Inventors:

Shan Jiang - Trumbull CT, US
Qishan Wang - Markham, CA
Xiaoyong Gao - Suzhou, CN

Assignee:

ASCEPION PHARMACEUTICALS, INC. - Suzhou, Jiangsu

International Classification:

C07D 401/06
C07D 471/04

US Classification:

514300, 5462774, 514339, 546113

Abstract:

The present invention provides deuterium-enriched heteroaryl-containing urea compounds (I) and use of the same for treating conditions mediated by protein kinase such as