Shalaby W Shalaby

US Patent:

6342065, Jan 29, 2002

Filed:

Mar 13, 2000

Appl. No.:

09/523754

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Pendleton SC

International Classification:

A61B 1704

US Classification:

606230, 606231, 525415, 528354

Abstract:

The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably -caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150Â C. and a crystallinity of at least 25%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1. 4 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yarns of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

US Patent:

6395259, May 28, 2002

Filed:

Dec 16, 1999

Appl. No.:

09/464870

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Pendleton SC

International Classification:

A61K 716

US Classification:

424 57, 5253297, 5253298, 5253303, 525340, 525403, 525418, 526274, 526278, 524 81

Abstract:

A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are present in an amount of at least about 0. 1 percent by weight in each polymeric composition.

US Patent:

6413539, Jul 2, 2002

Filed:

Jan 29, 1998

Appl. No.:

09/016439

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Anderson SC

International Classification:

A61F 200

US Classification:

424426, 528272, 528275, 528354, 528361, 525439, 525450, 424 7803, 424 7806, 424425, 424457, 424462, 424486, 514506

Abstract:

The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.

US Patent:

6462169, Oct 8, 2002

Filed:

Oct 27, 2000

Appl. No.:

09/698527

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Pendleton SC

International Classification:

C08G 6308

US Classification:

528354, 528355, 528357, 528359, 525415, 623 115, 606228

Abstract:

An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent.

US Patent:

6479457, Nov 12, 2002

Filed:

Oct 9, 1998

Appl. No.:

09/169423

Inventors:

Shalaby W. Shalaby - Pendleton SC
Steven A. Jackson - Holliston MA
Francis X. Ignatious - Millville MA
Jacques-Pierre Moreau - Upton MA
Ruth M. Russell - Dublin, IE

Assignee:

Kinerton Limited - Dublin

International Classification:

A61K 3812

US Classification:

514 9, 514 11

Abstract:

A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.

US Patent:

6485749, Nov 26, 2002

Filed:

Nov 16, 2000

Appl. No.:

09/713860

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Pendelton SC

International Classification:

A61K 900

US Classification:

424486, 424484, 424489, 424 937

Abstract:

Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell micoporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked ionically or covalently to the ester chain which induces autocatalyzed hydrolysis.

US Patent:

6498229, Dec 24, 2002

Filed:

Sep 5, 2001

Appl. No.:

09/946430

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Anderson SC

International Classification:

C08G 6360

US Classification:

528302, 528354, 528357, 528361, 525437, 525411, 606 77, 606230

Abstract:

The present invention is directed to a method for the direct, one-step synthesis of crystalline segmented glycolide copolymers having less than 80 percent glycolide-based sequences in the copolyester chain. The copolyester chain can also be formed using a polyether glycol as the initiator for the ring-opening copolymerization of glycolide and other cyclic monomers to form highly hydrophilic materials.

US Patent:

6503991, Jan 7, 2003

Filed:

Dec 14, 2000

Appl. No.:

09/737053

Inventors:

Shalaby W. Shalaby - Anderson SC

Assignee:

Poly-Med, Inc. - Anderson SC

International Classification:

C08G 6302

US Classification:

525437, 525411, 525439, 528302, 606151, 606154, 606230

Abstract:

The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or -caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.

Author:

Shalaby W. Shalaby

ISBN #:

0841221014

Author:

Shalaby W. Shalaby

ISBN #:

0841221650

Author:

Shalaby W. Shalaby

ISBN #:

0841227322

Author:

Shalaby W. Shalaby

ISBN #:

0841233772

Author:

Shalaby W. Shalaby

ISBN #:

0841235856

Author:

Shalaby W. Shalaby

ISBN #:

0849314844

Author:

Shalaby W. Shalaby

ISBN #:

0849315301

Author:

Shalaby W. Shalaby

ISBN #:

0891680160