Abstract:
The disclosure provides methods and uses for alleviating and/or treating pain including pain disorders using melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is 0, S or NR; Y is chosen from hydrogen, aryl, heteroaryl, C-Calkyl, C-Ccycloalkyl, and R is chosen from hydrogen, hydroxyl, —OCF, CF, C-Calkyl, C-Calkyloxy, C-Calkylthio, halogen and —Z—(CH-A; Ris chosen from C-Calkyl, C-Ccycloalkyl, CF, hydroxy-substituted C-Calkyl, hydroxy-substituted C-Ccycloalkyl, and NHR, wherein Ris H, C-Calkyl or C-Ccycloalkyl; Ris chosen from hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris chosen from hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl and halogen; R and Rmay be connected together to form an -0-(CH)bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; Ris chosen from hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris chosen from hydrogen and C-Calkyl; Ris chosen from hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl and halogen; and Ris chosen from hydrogen and C-Calkyl.