Selwyn A Broitman

Author:

Selwyn A. Broitman

ISBN #:

0884162192

US Patent:

52308863, Jul 27, 1993

Filed:

Mar 18, 1992

Appl. No.:

7/853132

Inventors:

Steven P. Treon - W. Roxbury MA
Selwyn A. Broitman - Newton Highlands MA

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K 4500
A61K 3766
A61K 3702
A61K 3704

US Classification:

424 851

Abstract:

A method for treating a cancer includes administration of an endotoxin to a patient at least a portion of whose neoplastic cells express the CD14 surface receptor. The endotoxin can be administered concurrently or sequentially with a binding protein capable of binding the endotoxin and, for example, where the endotoxin is a lipopolysaccharide or a nontoxic portion of a lipopolysaccharide, it may for example be administered concurrently with a lipopolysaccharide binding protein. Also, the method including a step of first determining whether a portion of the patient's neoplastic cells express the CD14 surface receptor and, if not, administering to the patient prior to or concurrently with the endotoxin a cytokine. Also, a composition for treating a cancer, that includes an endotoxin in combination with at least one cytokine. Administration of the composition can provide more effective treatment of cancers than administration of a composition containing one or more cytokines alone.