Seemab S Shaikh

US Patent:

20130189772, Jul 25, 2013

Filed:

Apr 25, 2011

Appl. No.:

13/696488

Inventors:

Seemab Shaikh - Lebanon NH, US

International Classification:

C12M 1/34

US Classification:

4352971

Abstract:

A multiwell-plate reactor is provided herein for small scale cell culturing and fermenting. Advantageously, with the multiwell-plate reactor of the subject invention, a small scale cell culturing and fermenting process can be conducted with the fluid, such as a liquid nutrient or one or more gases, being introduced in a controlled manner.

US Patent:

20150299648, Oct 22, 2015

Filed:

Nov 22, 2013

Appl. No.:

14/647874

Inventors:

- Rahway NJ, US
Marc D'Anjou - Enfield NH, US
Muralidhar R. Mallem - Lebanon NH, US
Ishaan Shandil - Nashua NH, US
Adam Nylen - Enfield NH, US
Nathan Sharkey - Plainfield NH, US
Seemab S. Shaikh - Lebanon NH, US

Assignee:

Merck Sharp & Dohme Corp - Rahway NJ

International Classification:

C12N 1/16
C07K 16/00
C07K 14/62

Abstract:

The present invention provides optimized cell culture media and fed-batch cultivation processes to improve the viability and volumetric production of heterologous proteins in . The disclosed media and processes utilize a non-fermentable sugar or sugar alcohol as an osmoprotectant to improve the robustness of production strains during methanol inducible fermentation.