A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, cancer, dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, , and , candidiasis (moniliasis), , tinea (pityriasis) vesicolor, , acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma.
Methods For Overcoming Wnt/Beta-Catenin Anti-Cancer Resistance In Leukemia Stem Cells
Linheng Li - Kansas City MO, US John M. Perry - Olathe KS, US Fang Tao - Overland Park KS, US Xi C. He - Kansas City MO, US Anuradha Roy - Kansas City MO, US Scott J. Weir - Overland Park KS, US Tara Lin - Mission Hills KS, US
International Classification:
A61K 31/704 A61K 39/395 C07K 16/28 A61P 35/02
Abstract:
The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.
Methods Of Forming Cyclopirox Or Derivatives Thereof In A Subject By Administration Of Prodrug
A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically acceptable salt thereof; and administering the composition to a subject such that the prodrug compound has a phosphoryloxyalkyl prodrug moiety removed therefrom to form the compound in the subject and to form the separate phosphoryloxyalkyl compound. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, various cancers (e.g., bladder, breast, etc.), dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, , and , candidiasis (moniliasis), , tinea (pityriasis) vesicolor, , acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma.
Method Of Treatment With Prodrugs Of 6-Cyclohexyl-1-Hydroxy-4-Methylpyridin In-2-1H-One And Derivatives Thereof
Mehmet Tanol - Lawrence KS, US Scott J. Weir - Lawrence KS, US
Assignee:
The University of Kansas - Lawrence KS
International Classification:
C07F 9/6596 C07F 9/59
US Classification:
514 89
Abstract:
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, cancer, dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, , and , candidiasis (moniliasis), , tinea () vesicolor, , acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma.