Chandan Sen - New Albany OH, US Savita Khanna - New Albany OH, US Sashwati Roy - New Albany OH, US Sangly Srinivas - Bloomington IN, US
International Classification:
G01N 21/64
US Classification:
422082080
Abstract:
An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).
Methods And Compositions For The Topical Oxygenation Of Hypoxic Tissue
Chandan K. Sen - New Albany OH, US Sashwati Roy - New Albany OH, US Savita Khanna - New Albany OH, US
Assignee:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH
International Classification:
A61K 38/16 A61P 17/02 A61M 37/00
US Classification:
514 6, 600 21
Abstract:
The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted.
Cameron L. Rink - Galloway OH, US Sashwati Roy - New Albany OH, US Savita Khanna - New Albany OH, US
Assignee:
The Ohio State University - Columbus OH
International Classification:
A61K 31/353 A61K 45/06
US Classification:
424 857, 514456, 424 854, 514 43
Abstract:
The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.
Method Of Ameliorating Clotting Pathologies And Related Materials And Methods
Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.
Chadan Sen - New Albany OH, US Sashwati Roy - New Albany OH, US Savita Khanna - New Albany OH, US
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
A61K031/355
US Classification:
514458000
Abstract:
Therapeutic and prophylactic agents comprising tocotrienols, and methods of using the same are provided for the treatment of and the prevention of the onset of stroke and other disorders and diseases associated with elevated glutamate levels, and the effects of lipoxygenases such as the enzyme 12-lipoxygenase.
Topical Tocotrienol Compositions And Methods Of Increasing Skin Stem Cells
- Columbus OH, US Savita KHANNA - Columbus OH, US Subhadip GHATAK - Columbus OH, US
International Classification:
A61K 31/355 A61K 9/00 A61K 47/44
Abstract:
The present disclosure relates to topical tocotrienol compositions, dosing regimens, and methods for increasing the stem cell content of the skin. The present invention further relates to topical tocotrienol compositions, dosing regimens, and methods for the treatment of skin disorders.
Method Of Ameliorating Clotting Pathologies And Related Materials And Methods
Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.
Methods For Reducing The Occurrence Of Hot Flashes
- Columbus OH, US Sashwati Roy - Upper Arlington OH, US Savita Khanna - Columbus OH, US Cameron Rink - Lewis Center OH, US
Assignee:
Ohio State Innovation Foundation - Columbus OH
International Classification:
A61K 31/355 A61K 45/06
Abstract:
The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.