Gary T. Norman - Middletown DE, US Kalyan S. Nuguru - Mantua NJ, US Arun F. Amin - Wilmington DE, US Sarath Chandar - Moorestown NJ, US
Assignee:
SPI Pharma, Inc. - Wilmington DE
International Classification:
A61K 9/14 A61K 9/20 A61K 9/26 A61K 9/46
US Classification:
424489, 424464, 424466, 424469
Abstract:
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
Co-Processed Carbohydrate System As A Quick-Dissolve Matrix For Solid Dosage Forms
Gary Norman - Middletown DE, US Kalyan Nuguru - Mantua NJ, US Arun Amin - Wilmington DE, US Sarath Chandar - Moorestown NJ, US
International Classification:
A61K009/20 B29B009/00
US Classification:
424/465000, 264/005000
Abstract:
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
Arun F. Amin - Wilmington DE, US Sarath Chandar - Moorestown NJ, US Adrian Gilbert - Ra'anana, IL Dannit Licht - Givat Shmuel, IL Gary T. Norman - Houghton-Le-Spring, GB Shuli Patashnik - Reut, IL
International Classification:
A61K 9/20 A61K 47/10
US Classification:
424465, 514772
Abstract:
This invention provides a solid pharmaceutical composition comprising an active ingredient (e.g., rasagiline) or a pharmaceutically acceptable salt thereof, and particles having a non-filamentous microstructure of at least two sugar alcohols. This invention also provides a solid pharmaceutical composition comprising an active ingredient (e.g., rasagiline) or a pharmaceutically acceptable salt thereof, a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols, a supplemental sugar alcohol, a supplemental flow agent, and a supplemental disintegrant. Finally, this invention provides a process of making such solid pharmaceutical compositions.
Co-Processed Carbohydrate System As A Quick-Dissolve Matrix For Solid Dosage Forms
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
Co-Processed Carbohydrate System As A Quick-Dissolve Matrix For Solid Dosage Forms
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.