Sarah L Elson

US Patent:

6781028, Aug 24, 2004

Filed:

Jun 14, 1999

Appl. No.:

09/332522

Inventors:

Michael R. Costa - San Francisco CA
Stephen K. Doberstein - San Francisco CA
Sarah L. Elson - San Francisco CA
Kimberly Carr Ferguson - Burlingame CA
Sheila Akiko Homburger - Oakland CA

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

G01N 3300

US Classification:

800 3, 800 13, 4353201, 435325, 536 231

Abstract:

and that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living nematodes using fluorescently-labelled fatty acid conjugates, such BODITYâ fatty acid conjugates, are also described. Novel SREBP pathway nucleic acid and protein sequences are also described.