Sarah J Barilovits

US Patent:

20130315974, Nov 28, 2013

Filed:

Oct 28, 2011

Appl. No.:

13/882263

Inventors:

Harry S. Nick - Gainesville FL, US
Kimberly J. Aiken - Alachua FL, US
Sarah J. Barilovits - Charlotte NC, US
Justin S. Bickford - Gainesville FL, US
Dawn E. Beachy - Gainesville FL, US

Assignee:

University of Florida Research Foundation,Inc. - Gainesville FL

International Classification:

A61K 31/7004
G01N 33/50

US Classification:

424432, 536 111, 514 23, 435 29

Abstract:

Disclosed herein are compositions and methods for controlling fertility of a female subject. Particularly exemplified are compositions comprising sugar derivatives, such as 2-deoxyglucose, D-mannoheptulose; and/or 5-thio-D-glucose. Also disclosed herein are methods of preserving ova supply in a female subject that involves administering glucose derivatives. The composition typically includes a glucose derivative that affects Foxo3a expression.

US Patent:

20190366295, Dec 5, 2019

Filed:

Aug 16, 2019

Appl. No.:

16/543379

Inventors:

- Pleasanton CA, US
Sarah Barilovits - Madison WI, US
Jigar Patel - Verona WI, US
Eric Sullivan - Madison WI, US
John Tan - Madison WI, US

International Classification:

B01J 19/00
G01N 33/68

Abstract:

The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.

US Patent:

20170120212, May 4, 2017

Filed:

Sep 8, 2016

Appl. No.:

15/259893

Inventors:

- Pleasanton CA, US
Sarah Barilovits - Madison WI, US
Jigar Patel - Verona WI, US
Eric Sullivan - Madison WI, US
John Tan - Madison WI, US

International Classification:

B01J 19/00
G01N 33/68

Abstract:

The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.

US Patent:

20170059578, Mar 2, 2017

Filed:

Aug 10, 2016

Appl. No.:

15/233543

Inventors:

- Pleasanton CA, US
Sarah Barilovits - Madison WI, US
Jigar Patel - Verona WI, US
Eric Sullivan - Madison WI, US
John Tan - Madison WI, US

International Classification:

G01N 33/68
G01N 21/64
B01J 19/00

Abstract:

The present invention provides a system and method for assessing the fidelity of a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a plurality of binder sequences. A first amino acid is at a defined position within a first one of the binder sequences, and the population of peptide features includes a first control peptide feature synthesized to have an amino acid sequence including the first one of the binder sequences. The system and method further includes detecting a signal output characteristic of an interaction of the receptor with the first control peptide feature. The signal output is indicative of the fidelity of incorporation of the first amino acid into the first control peptide at the defined position within the first one of the binder sequences.