Adnan M. M. Mjalli - Jamestown NC, US Bapu R. Gaddam - Greensboro NC, US Ghassan Qabaja - High Point NC, US Govindan Subramanian - High Point NC, US Jeff Zhu - Greensboro NC, US John Dankwardt - Westborough MA, US Murty N. Arimilli - Oak Ridge NC, US Robert C. Andrews - Jamestown NC, US Samuel Victory - Oak Ridge NC, US Ye E. Tian - Jamestown NC, US
Assignee:
TransTech Pharma, Inc. - High Point NC
International Classification:
A61K 31/427 A61K 31/381 C07D 277/38 C07D 409/12
US Classification:
514370, 514444, 548194, 549 59
Abstract:
The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
Adnan M. M. Mjalli - Oak Ridge NC, US Bapu Gaddam - High Point NC, US Robert C. Andrews - Jamestown NC, US Samuel Victory - Oak Ridge NC, US Suparna Gupta - Greensboro NC, US
Assignee:
High Point Pharmaceuticals, LLC - High Point NC
International Classification:
A61K 31/427 C07D 417/12
US Classification:
548194, 514370
Abstract:
Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
2-Substituted Bicyclic Benzoheterocyclic Compounds And Their Use As Sodium Channel Blockers
This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel 2-substituted bicyclic benzoheterocyclic compounds of Formula I: or a pharmaceutically-acceptable salt or solvate thereof, wherein X is —NH—, —N or —S—, Y is oxygen or sulfur, and n, p, R, R, Rand Rare defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
4-Phenylsulfonamidopiperidines As Calcium Channel Blockers
Elfrida R. Benjamin - Millstone Township NJ, US Zhengming Chen - Belle Meade NJ, US Deyou Sha - Yardley PA, US Laykea Tafesse - Robbinsville NJ, US Samuel F. Victory - Oak Ridge NC, US John W.F. Whitehead - Newtown PA, US Xiaoming Zhou - Plainsboro NJ, US
Adnan M. M. Mjalli - Oak Ridge NC, US Dharma Rao Polisetti - High Point NC, US Jareer Nabeel Kassis - Colfax NC, US Matthew J. Kostura - Hillsborough NC, US Mustafa Guzel - Jamestown NC, US Otis Clinton Attucks - Winston-Salem NC, US Robert Carl Andrews - Jamestown NC, US Samuel Victory - Oak Ridge NC, US Suparna Gupta - Greensboro NC, US
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.