Sally P Mossman from 9308 Falls Bridge Ln, Rockville, MD 20854, age 60, Phone: 301 299-0463

Resumes

Sally Mossman

view source

Us Patents

Microspheres And Adjuvants For Dna Vaccine Delivery
view source
US Patent:

20020032165, Mar 14, 2002
Filed:

Jul 9, 2001
Appl. No.:

09/901829
Inventors:

Mark Johnson - Bellevue WA, US
Sally Mossman - Seattle WA, US
Tricia Cecil - Bellevue WA, US
Lawrence Evans - Seattle WA, US
International Classification:

A61K048/00
A61K009/16
A61K009/50
US Classification:

514/044000, 514/062000, 424/493000
Abstract:

A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic acid delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery of DNA vaccines. The invention further provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention further provides an adjuvant for modulating the immunostimulatory efficacy of microsphetes encapsulating nucleic acid molecules comprising an aminoalkyl glucosanide -phosphate (AGP). The invention also provides a method for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules.

Compositions And Methods For The Diagnosis And Threatment Of Herpes Simplex Virus Infection
view source
US Patent:

20030068327, Apr 10, 2003
Filed:

Apr 11, 2002
Appl. No.:

10/121988
Inventors:

Nancy Hosken - Seattle WA, US
Patrick McGowan - Seattle WA, US
Paul Sleath - Seattle WA, US
Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
Ryan Swanson - Seattle WA, US
Patricia McNeill - Federal Way WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K039/12
C12N009/50
C07H021/04
C12P021/06
US Classification:

424/186100, 435/219000, 536/023720, 435/069100
Abstract:

Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.

Compositions And Methods For Wt1 Specific Immunotherapy
view source
US Patent:

20030072767, Apr 17, 2003
Filed:

Aug 24, 2001
Appl. No.:

09/938864
Inventors:

Alexander Gaiger - Seattle WA, US
Patricia McNeill - Federal Way WA, US
Molly Smithgall - Seattle WA, US
Gus Moulton - Seattle WA, US
Thomas Vedvick - Federal Way WA, US
Paul Sleath - Seattle WA, US
Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
A. Spies - Shoreline WA, US
Jeremy Boydston - Seattle WA, US
International Classification:

A61K039/00
C07H021/04
C12N009/64
C12P021/02
C12N005/06
US Classification:

424/185100, 435/069100, 435/226000, 435/320100, 435/325000, 536/023200
Abstract:

Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

Compositions And Methods For Wt1 Specific Immunotherapy
view source
US Patent:

20030095971, May 22, 2003
Filed:

Oct 30, 2001
Appl. No.:

10/002603
Inventors:

Alexander Gaiger - Seattle WA, US
Patricia McNeill - Federal Way WA, US
Molly Smithgall - Seattle WA, US
Gus Moulton - Seattle WA, US
Thomas Vedvick - Federal Way WA, US
Paul Sleath - Seattle WA, US
Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
A. Spies - Shoreline WA, US
Jeremy Boydston - Seattle WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K048/00
A61K039/395
A61K039/00
C12N009/00
C12P021/02
C12N005/06
US Classification:

424/155100, 424/093210, 536/023200, 435/183000, 435/325000, 435/320100, 435/069100
Abstract:

Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

Immunostimulant Compositions Comprising An Aminoalkyl Glucosaminide Phosphate And Qs-21
view source
US Patent:

20030147920, Aug 7, 2003
Filed:

Jun 21, 2002
Appl. No.:

10/177115
Inventors:

Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K039/02
A61K031/739
US Classification:

424/234100, 514/054000
Abstract:

The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.

Immunostimulant Compositions Comprising Aminoalkyl Glucosaminide Phosphates And Saponins
view source
US Patent:

20030190333, Oct 9, 2003
Filed:

Feb 4, 2002
Appl. No.:

10/068171
Inventors:

Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
Jory Baldridge - Victor MT, US
Jay Evans - Corvallis MT, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K039/02
A61K031/739
US Classification:

424/234100, 514/042000, 514/054000
Abstract:

The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising at least one aminoalkyl glucosaminide phosphate compound and at least one saponin compound. Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.

Compositions And Methods For Wt1 Specific Immunotherapy
view source
US Patent:

20030198622, Oct 23, 2003
Filed:

Jul 12, 2002
Appl. No.:

10/195835
Inventors:

Alexander Gaiger - Seattle WA, US
Molly Smithgall - Seattle WA, US
Darrick Carter - Seattle WA, US
Martin Cheever - Mercer Island WA, US
Patricia McNeill - Federal Way WA, US
R. Sutherland - Bothell WA, US
Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
Ryan Swanson - Seattle WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K048/00
A61K039/00
C07K014/47
C12N005/08
US Classification:

424/093200, 514/044000, 424/185100, 530/350000, 435/372000
Abstract:

Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

Compositions And Methods For Viral Delivery
view source
US Patent:

20030228279, Dec 11, 2003
Filed:

Oct 29, 2002
Appl. No.:

10/283484
Inventors:

Sally Mossman - Seattle WA, US
Lawrence Evans - Seattle WA, US
Ryan Swanson - Seattle WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K048/00
A61K038/20
A61K038/19
A61K031/739
US Classification:

424/093200, 514/054000, 424/085100, 424/085200, 536/053000
Abstract:

Compositions and methods comprising a recombinant virus and an immunostimulant are provided for enhancing the immune response to a polypeptide expressed from the recombinant virus. Preferably this is done without also enhancing the neutralizing antibody response to the recombinant virus. Illustrative compositions comprise an adenovirus and an adjuvant such as, for example, monophosphoryl lipid A, an alkyl glucosaminide phosphate, a saponin, or a combination thereof. The disclosed compositions and methods are useful, for example, in the treatment of diseases such as cancer or infectious disease.