Ryan O O'Connell

US Patent:

20080300211, Dec 4, 2008

Filed:

May 16, 2008

Appl. No.:

12/122595

Inventors:

David Baltimore - Pasadena CA, US
Ryan O'Connell - Pasadena CA, US
Konstantin Taganov - Pasadena CA, US
Mark Boldin - Pasadena CA, US

International Classification:

A61K 31/70
C12N 5/06
A61P 31/00

US Classification:

514 44, 435375

Abstract:

The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.

US Patent:

20090124573, May 14, 2009

Filed:

Nov 9, 2008

Appl. No.:

12/267602

Inventors:

SARKIS MAZMANIAN - PASADENA CA, US
JUNE L. ROUND - PASADENA CA, US
RYAN MICHAEL O'CONNELL - PASADENA CA, US
DENNIS L. KASPER - Brookline MA, US

International Classification:

A61K 31/715
A61P 29/00

US Classification:

514 54

Abstract:

Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.

US Patent:

20110002965, Jan 6, 2011

Filed:

Jul 6, 2010

Appl. No.:

12/831131

Inventors:

June L. Round - Pasadena CA, US
Sarkis Mazmanian - Pasadena CA, US
Ryan Michael O'Connell - Pasadena CA, US
Dennis L. Kasper - Brookline MA, US

International Classification:

A61K 31/715
A61P 1/00
A61P 11/06
A61P 17/00
A61P 19/02
A61P 17/06
A61P 5/14
A61P 29/00

US Classification:

4242821

Abstract:

Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.

US Patent:

20120064122, Mar 15, 2012

Filed:

Sep 12, 2011

Appl. No.:

13/230695

Inventors:

David Baltimore - Pasadena CA, US
Ryan M. O'Connell - Pasadena CA, US
Daniel Kahn - Calabasas CA, US

International Classification:

A61K 31/7088
A61P 37/04
A61P 31/00
A61P 31/04
A61P 31/12
C12N 5/0784
A61P 25/00
A61P 19/02
A61P 1/00
A61P 17/06
C12N 5/0783
A61P 29/00
A61P 37/00

US Classification:

4242781, 514 44 A, 435375

Abstract:

The present disclosure relates to the finding that microRNA-155 plays a role in the development and activity of CD4+ T cells. CD4+ T cell development and function, particularly T17 and T1 T cell development, can be modulated by delivery of microRNA-155 (miR-155) or antisense miR-155 to target CD4+ cells or precursor cells. In some embodiments, antisense miR-155 is used to reduce tissue specific autoimmune inflalmmation and to treat autoimmune disease. In addition, miR155 and antisense miR-155 can be used to modulate expression of cytokines from dendritic cells.

US Patent:

20120065245, Mar 15, 2012

Filed:

Sep 12, 2011

Appl. No.:

13/230673

Inventors:

David Baltimore - Pasadena CA, US
Ryan M. O'Connell - Pasadena CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

A61K 31/7088
A61P 35/02
A61P 35/00
A61P 7/06
A61P 7/00

US Classification:

514 44 A

Abstract:

The present disclosure relates to regulation of functions of hematopoietic stem cells (HSCs) by delivering of miRNAs, including miR-125b, miR-126, and miR-155, to HSCs. For example, in some embodiments, blood output in a mammal can be increased by administering miR-125b, miR-126, and/or miR-155 oligonucleotides. Also disclosed are methods for promoting hematopoietic stem cell engraftment and method for treating a myeloproliferative disorder.

US Patent:

20130039949, Feb 14, 2013

Filed:

May 4, 2012

Appl. No.:

13/464876

Inventors:

Sarkis MAZMANIAN - Pasadena CA, US
June L. ROUND - Pasadena CA, US
Ryan Michael O'CONNELL - Pasadena CA, US
Dennis L. KASPER - Charlestown MA, US

International Classification:

A61K 31/715
A61P 29/00
A61P 37/02

US Classification:

4242821, 4242781

Abstract:

Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.

US Patent:

20200197436, Jun 25, 2020

Filed:

Sep 5, 2019

Appl. No.:

16/562358

Inventors:

- Pasadena CA, US
- Boston MA, US
Ryan Michael O'CONNELL - Pasadena CA, US
Dennis L. KASPER - Charlestown MA, US

International Classification:

A61K 31/715
A61K 35/74

Abstract:

Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.

US Patent:

20190022128, Jan 24, 2019

Filed:

Oct 4, 2018

Appl. No.:

16/151793

Inventors:

- Pasadena CA, US
- Boston MA, US
Ryan Michael O'Connell - Pasadena CA, US
Dennis L. Kasper - Charlestown MA, US

International Classification:

A61K 31/715

Abstract:

Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.