Ruth A Gjerset

US Patent:

8431353, Apr 30, 2013

Filed:

Oct 6, 2010

Appl. No.:

12/898872

Inventors:

Ruth A. Gjerset - San Diego CA, US
Keya Bandyopadhyay - San Diego CA, US

Assignee:

RG Biopharma LLC - San Diego CA

International Classification:

G01N 33/574
C12Q 1/00
A01N 43/42

US Classification:

435 723, 435 4, 514283

Abstract:

Disclosed herein are methods and compositions for determining the sensitivity or enhancing the sensitivity of cells to the effects of topoisomerase I inhibitors. Also disclosed are methods and compositions for inducing cell death, apoptosis and/or growth arrest which may be used for tumor suppression.

US Patent:

20020006914, Jan 17, 2002

Filed:

Jan 26, 2001

Appl. No.:

09/769752

Inventors:

Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.

US Patent:

20020010144, Jan 24, 2002

Filed:

Jan 10, 2001

Appl. No.:

09/758956

Inventors:

Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.

US Patent:

20040072775, Apr 15, 2004

Filed:

Feb 25, 2003

Appl. No.:

10/374665

Inventors:

Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.

US Patent:

20050032728, Feb 10, 2005

Filed:

Nov 19, 2003

Appl. No.:

10/717845

Inventors:

Ruth Gjerset - San Diego CA, US
Yinghui Huang - San Diego CA, US
Neshat Saadatmandi - San Diego CA, US

International Classification:

A61K048/00
A61K009/127
C12N015/86

US Classification:

514044000, 424450000, 435320100, 435456000

Abstract:

A bicistronic construct of pand pARF, vectors and other delivery vehicles which include the bicistronic construct, and methods of treating cancer using the vectors and bicistronic construct.

US Patent:

20050095226, May 5, 2005

Filed:

May 10, 2004

Appl. No.:

10/842718

Inventors:

Ruth Gjerset - San Diego CA, US

International Classification:

A61K048/00
A61K038/17
C12N015/861

US Classification:

424093200, 435456000, 514012000

Abstract:

The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53 gene therapy. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 gene therapy is involved in restoration of p53-mediated apoptosis.

US Patent:

20110028536, Feb 3, 2011

Filed:

Aug 16, 2007

Appl. No.:

12/377498

Inventors:

Ruth A. Gjerset - San Diego CA, US
Keya Bandyopadhyay - San Diego CA, US

International Classification:

A61K 31/7088
C12N 5/071
A61K 31/4375
C12Q 1/68
C12N 5/09
A61P 35/00

US Classification:

514 44 R, 435325, 514283, 435 6

Abstract:

Disclosed herein are methods and compositions for enhancing the sensitivity of cells to the effects of topoisomerase I inhibitors. Also disclosed are methods and compositions for inducing apoptosis and/or growth arrest which may be used for tumor suppression.

US Patent:

60544678, Apr 25, 2000

Filed:

Jul 5, 1996

Appl. No.:

8/675887

Inventors:

Ruth A. Gjerset - San Diego CA

Assignee:

Sidney Kimmel Cancer Center - San Diego CA

International Classification:

A01N 4342
A01N 3718
A61K 3147
A61K 31165

US Classification:

514309

Abstract:

The present invention details methods for the treatment of cancer. In particular it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 is involved in restoration of p53-mediated apoptosis.