Christopher P. Rusconi - Durham NC, US Ross M. Tonkens - Cary NC, US
International Classification:
A61K 31/7088
US Classification:
514 44
Abstract:
An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing activity of the aptamer to a desired extent is provided where an antidote dose is based solely on its relationship to the aptamer dose.