Harris Busch - Houston TX James W. Freeman - Houston TX Rose K. Busch - Houston TX
Assignee:
Biosciences Corporation of Texas - Houston TX
International Classification:
G01N 3353 C12N 500 C07K 320
US Classification:
435 7
Abstract:
Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purifed. Monoclonal antibodies specific to one of these nucleolar antigens (p145) are harvested from mouse ascites or culture supernatant and used for detection of human The Government may have rights in this invention subject to funding grants provided by the Department of Health and Human Services No. 5 PO1-CA-10893-19.
Detection Of Human Cancer Cells With Antibodies To Human Cancer Nucleolar Antigens
Karel Smetana - Prague, CS Harris Busch - Houston TX Rose K. Busch - Houston TX Ferenc Gyorkey - Houston TX Phyllis Gyorkey - Houston TX Frances M. Davis - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
G01N 3354 G01N 3358 C07G 700
US Classification:
436508
Abstract:
Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigens are harvested from non-human hosts and used for detection of human cancer cells. Disclosed are (1) methods for isolating the nucleolar antigens, obtaining them in substantially purified form, producing the specific antibodies, obtaining them in substantially purified form, and using the antisera and antibodies induced by the nucleolar antigens in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies and antisera.
Harris Busch - Houston TX Clarence Frank Bennett - Carlsbad CA Laszlo Perlaky - Houston TX Yasuo Saijo - Sendai, JP Rose K. Busch - Houston TX
Assignee:
Baylor College of Medicine - Houston TX ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100 A61K 4800
US Classification:
536 245
Abstract:
Oligonucleotides capable of inhibiting the production of proliferation-associated proteins are provided. Oligonucleotides designed to be hybridizable with nucleic acids encoding nucleolar proteins are believed to be therapeutically useful. Certain of such oligonucleotides, hybridizable to portions of the gene coding for p120, especially the 3' untranslated region, were made and found to inhibit the synthesis of p120. The oligonucleotides of the invention are useful for the treatment of diseases characterized by hyperproliferation of cells such as malignancies, inflammatory and cardiovascular diseases. Treatment of human breast cell carcinoma, human epitheloid cervix carcinoma, human amelanotic melanoma, human renal cell carcinoma and other tumors are indicated.
Name / Title
Company / Classification
Phones & Addresses
Rose Busch Secretary, Vice President
H. Busch Corp
4966 Dumfries Dr, Houston, TX 77096
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