Rose K Busch

US Patent:

47940778, Dec 27, 1988

Filed:

Dec 13, 1985

Appl. No.:

6/808913

Inventors:

Harris Busch - Houston TX
James W. Freeman - Houston TX
Rose K. Busch - Houston TX

Assignee:

Biosciences Corporation of Texas - Houston TX

International Classification:

G01N 3353
C12N 500
C07K 320

US Classification:

435 7

Abstract:

Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purifed. Monoclonal antibodies specific to one of these nucleolar antigens (p145) are harvested from mouse ascites or culture supernatant and used for detection of human The Government may have rights in this invention subject to funding grants provided by the Department of Health and Human Services No. 5 PO1-CA-10893-19.

US Patent:

44488904, May 15, 1984

Filed:

Sep 29, 1980

Appl. No.:

6/191612

Inventors:

Karel Smetana - Prague, CS
Harris Busch - Houston TX
Rose K. Busch - Houston TX
Ferenc Gyorkey - Houston TX
Phyllis Gyorkey - Houston TX
Frances M. Davis - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

G01N 3354
G01N 3358
C07G 700

US Classification:

436508

Abstract:

Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigens are harvested from non-human hosts and used for detection of human cancer cells. Disclosed are (1) methods for isolating the nucleolar antigens, obtaining them in substantially purified form, producing the specific antibodies, obtaining them in substantially purified form, and using the antisera and antibodies induced by the nucleolar antigens in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies and antisera.

US Patent:

56567430, Aug 12, 1997

Filed:

Nov 18, 1994

Appl. No.:

8/290936

Inventors:

Harris Busch - Houston TX
Clarence Frank Bennett - Carlsbad CA
Laszlo Perlaky - Houston TX
Yasuo Saijo - Sendai, JP
Rose K. Busch - Houston TX

Assignee:

Baylor College of Medicine - Houston TX
ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2100
A61K 4800

US Classification:

536 245

Abstract:

Oligonucleotides capable of inhibiting the production of proliferation-associated proteins are provided. Oligonucleotides designed to be hybridizable with nucleic acids encoding nucleolar proteins are believed to be therapeutically useful. Certain of such oligonucleotides, hybridizable to portions of the gene coding for p120, especially the 3' untranslated region, were made and found to inhibit the synthesis of p120. The oligonucleotides of the invention are useful for the treatment of diseases characterized by hyperproliferation of cells such as malignancies, inflammatory and cardiovascular diseases. Treatment of human breast cell carcinoma, human epitheloid cervix carcinoma, human amelanotic melanoma, human renal cell carcinoma and other tumors are indicated.