The invention provides isolated nucleic acids molecules, designated 24554 nucleic acid molecules, which encode novel ubiquitin carboxy-terminal hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 24554 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 24554 gene has been introduced or disrupted. The invention still further provides isolated 24554 proteins, fusion proteins, antigenic peptides and anti-24554 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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